ENSSDUP00000001113 protein (Seriola dumerili)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

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[Homology]

Score

ENSSDUP00000001113

Uncharacterized protein. (77 aa)

Predicted Functional Partners:

nup214

0.949

LOC111218510

0.916

ran

0.889

adgrd1

0.889

ranbp1

0.879

snupn

0.872

xpo1

0.824

nup98

0.730

nmd3

0.714

nxf1

0.708

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000001113	LOC111218510	ENSSDUP00000001113	ENSSDUP00000018015	Uncharacterized protein.	RAN binding protein 2.	0.916
ENSSDUP00000001113	adgrd1	ENSSDUP00000001113	ENSSDUP00000031584	Uncharacterized protein.	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	0.889
ENSSDUP00000001113	nmd3	ENSSDUP00000001113	ENSSDUP00000033028	Uncharacterized protein.	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.	0.714
ENSSDUP00000001113	nup214	ENSSDUP00000001113	ENSSDUP00000016901	Uncharacterized protein.	Nup214_FG domain-containing protein.	0.949
ENSSDUP00000001113	nup98	ENSSDUP00000001113	ENSSDUP00000009014	Uncharacterized protein.	Nucleoporin 98.	0.730
ENSSDUP00000001113	nxf1	ENSSDUP00000001113	ENSSDUP00000023805	Uncharacterized protein.	Zgc:153681.	0.708
ENSSDUP00000001113	ran	ENSSDUP00000001113	ENSSDUP00000020401	Uncharacterized protein.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.889
ENSSDUP00000001113	ranbp1	ENSSDUP00000001113	ENSSDUP00000003127	Uncharacterized protein.	RAN binding protein 1.	0.879
ENSSDUP00000001113	snupn	ENSSDUP00000001113	ENSSDUP00000032649	Uncharacterized protein.	Snurportin 1.	0.872
ENSSDUP00000001113	xpo1	ENSSDUP00000001113	ENSSDUP00000001086	Uncharacterized protein.	Exportin 1 (CRM1 homolog, yeast) a.	0.824
LOC111218510	ENSSDUP00000001113	ENSSDUP00000018015	ENSSDUP00000001113	RAN binding protein 2.	Uncharacterized protein.	0.916
LOC111218510	adgrd1	ENSSDUP00000018015	ENSSDUP00000031584	RAN binding protein 2.	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	0.983
LOC111218510	nmd3	ENSSDUP00000018015	ENSSDUP00000033028	RAN binding protein 2.	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.	0.483
LOC111218510	nup214	ENSSDUP00000018015	ENSSDUP00000016901	RAN binding protein 2.	Nup214_FG domain-containing protein.	0.999
LOC111218510	nup98	ENSSDUP00000018015	ENSSDUP00000009014	RAN binding protein 2.	Nucleoporin 98.	0.997
LOC111218510	nxf1	ENSSDUP00000018015	ENSSDUP00000023805	RAN binding protein 2.	Zgc:153681.	0.992
LOC111218510	ran	ENSSDUP00000018015	ENSSDUP00000020401	RAN binding protein 2.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.983
LOC111218510	ranbp1	ENSSDUP00000018015	ENSSDUP00000003127	RAN binding protein 2.	RAN binding protein 1.	0.544
LOC111218510	snupn	ENSSDUP00000018015	ENSSDUP00000032649	RAN binding protein 2.	Snurportin 1.	0.717
LOC111218510	xpo1	ENSSDUP00000018015	ENSSDUP00000001086	RAN binding protein 2.	Exportin 1 (CRM1 homolog, yeast) a.	0.916

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.907

expected number of edges:

10

PPI enrichment p-value:

5.55e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030042

Actin filament depolymerization

3 of 11

2.71

1.91

0.00032

GO:0051014

Actin filament severing

3 of 16

2.55

1.85

0.00038

GO:0030043

Actin filament fragmentation

2 of 3

3.1

1.37

0.0034

GO:0030036

Actin cytoskeleton organization

6 of 512

1.35

1.27

0.00038

GO:0022604

Regulation of cell morphogenesis

4 of 196

1.59

1.14

0.0034

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003779

Actin binding

5 of 498

1.28

0.85

0.0087

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

5 of 376

1.4

1.19

0.0011

GO:0005925

Focal adhesion

3 of 112

1.7

0.97

0.0109

GO:0005856

Cytoskeleton

7 of 1877

0.85

0.6

0.0073

GO:0043232

Intracellular non-membrane-bounded organelle

8 of 3620

0.62

0.4

0.0212

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2568

ADF/Cofilin, and Sema3A PAK dependent Axon repulsion

3 of 6

2.98

2.42

4.03e-05

CL:2418

Mixed, incl. Dual specificity phosphatase, catalytic domain, and MAP kinase activity

4 of 89

1.93

1.83

0.00018

CL:1933

Parvin, and Integrin-linked protein kinase, pseudokinase domain

2 of 7

2.73

1.2

0.0067

CL:1398

Mixed, incl. Phenylalanine zipper, and Insulin receptor, trans-membrane domain

2 of 8

2.67

1.18

0.0071

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446388

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

3 of 11

2.71

2.27

6.62e-05

MAP-9020591

Interleukin-12 signaling

3 of 15

2.58

2.23

7.41e-05

MAP-447115

Interleukin-12 family signaling

3 of 21

2.43

2.09

0.00012

MAP-399954

Sema3A PAK dependent Axon repulsion

3 of 26

2.34

1.99

0.00017

MAP-446353

Cell-extracellular matrix interactions

3 of 32

2.25

1.89

0.00024

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 120

1.67

0.97

0.0106

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017904

ADF/Cofilin

3 of 3

3.28

2.67

1.53e-05

IPR002108

Actin-depolymerising factor homology domain

3 of 12

2.67

2.05

0.00017

IPR029006

ADF-H/Gelsolin-like domain superfamily

3 of 30

2.28

1.52

0.0014

IPR028433

Parvin

2 of 3

3.1

1.31

0.0044

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00102

Actin depolymerisation factor/cofilin -like domains

3 of 11

2.71

2.45

3.06e-05

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