| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LOC111233015 | atm | ENSSDUP00000028226 | ENSSDUP00000015925 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Non-specific serine/threonine protein kinase. | 0.998 |
| LOC111233015 | bard1 | ENSSDUP00000028226 | ENSSDUP00000019914 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | BRCA1 associated RING domain 1. | 0.872 |
| LOC111233015 | chek1 | ENSSDUP00000028226 | ENSSDUP00000005826 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Checkpoint kinase 1; Belongs to the protein kinase superfamily. | 0.992 |
| LOC111233015 | chek2 | ENSSDUP00000028226 | ENSSDUP00000026192 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Checkpoint kinase 2. | 0.996 |
| LOC111233015 | mdm2 | ENSSDUP00000028226 | ENSSDUP00000024048 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | MDM2 proto-oncogene. | 0.999 |
| LOC111233015 | mdm4 | ENSSDUP00000028226 | ENSSDUP00000002400 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. | 0.999 |
| LOC111233015 | rps27a | ENSSDUP00000028226 | ENSSDUP00000004225 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Ribosomal protein S27a. | 0.938 |
| LOC111233015 | tp53bp1 | ENSSDUP00000028226 | ENSSDUP00000026700 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Tumor protein p53 binding protein, 1. | 0.973 |
| LOC111233015 | tp73 | ENSSDUP00000028226 | ENSSDUP00000001976 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.769 |
| LOC111233015 | yap1 | ENSSDUP00000028226 | ENSSDUP00000026252 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Yes-associated protein 1. | 0.495 |
| atm | LOC111233015 | ENSSDUP00000015925 | ENSSDUP00000028226 | Non-specific serine/threonine protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.998 |
| atm | bard1 | ENSSDUP00000015925 | ENSSDUP00000019914 | Non-specific serine/threonine protein kinase. | BRCA1 associated RING domain 1. | 0.987 |
| atm | chek1 | ENSSDUP00000015925 | ENSSDUP00000005826 | Non-specific serine/threonine protein kinase. | Checkpoint kinase 1; Belongs to the protein kinase superfamily. | 0.985 |
| atm | chek2 | ENSSDUP00000015925 | ENSSDUP00000026192 | Non-specific serine/threonine protein kinase. | Checkpoint kinase 2. | 0.997 |
| atm | mdm2 | ENSSDUP00000015925 | ENSSDUP00000024048 | Non-specific serine/threonine protein kinase. | MDM2 proto-oncogene. | 0.953 |
| atm | mdm4 | ENSSDUP00000015925 | ENSSDUP00000002400 | Non-specific serine/threonine protein kinase. | MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. | 0.849 |
| atm | rps27a | ENSSDUP00000015925 | ENSSDUP00000004225 | Non-specific serine/threonine protein kinase. | Ribosomal protein S27a. | 0.649 |
| atm | tp53bp1 | ENSSDUP00000015925 | ENSSDUP00000026700 | Non-specific serine/threonine protein kinase. | Tumor protein p53 binding protein, 1. | 0.980 |
| atm | tp73 | ENSSDUP00000015925 | ENSSDUP00000001976 | Non-specific serine/threonine protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.841 |
| bard1 | LOC111233015 | ENSSDUP00000019914 | ENSSDUP00000028226 | BRCA1 associated RING domain 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.872 |
STRING v12.5 is now available!
