| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LOC111230695 | LOC111233015 | ENSSDUP00000019843 | ENSSDUP00000028226 | E3 ubiquitin-protein ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.848 |
| LOC111230695 | LOC111233556 | ENSSDUP00000019843 | ENSSDUP00000023022 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase. | 0.900 |
| LOC111230695 | mdm2 | ENSSDUP00000019843 | ENSSDUP00000024048 | E3 ubiquitin-protein ligase. | MDM2 proto-oncogene. | 0.635 |
| LOC111230695 | rps27a | ENSSDUP00000019843 | ENSSDUP00000004225 | E3 ubiquitin-protein ligase. | Ribosomal protein S27a. | 0.912 |
| LOC111230695 | tp73 | ENSSDUP00000019843 | ENSSDUP00000001976 | E3 ubiquitin-protein ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.858 |
| LOC111230695 | yap1 | ENSSDUP00000019843 | ENSSDUP00000026252 | E3 ubiquitin-protein ligase. | Yes-associated protein 1. | 0.577 |
| LOC111233015 | LOC111230695 | ENSSDUP00000028226 | ENSSDUP00000019843 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | E3 ubiquitin-protein ligase. | 0.848 |
| LOC111233015 | LOC111233556 | ENSSDUP00000028226 | ENSSDUP00000023022 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | E3 ubiquitin-protein ligase. | 0.848 |
| LOC111233015 | atm | ENSSDUP00000028226 | ENSSDUP00000015925 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Non-specific serine/threonine protein kinase. | 0.999 |
| LOC111233015 | chek1 | ENSSDUP00000028226 | ENSSDUP00000005826 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Checkpoint kinase 1; Belongs to the protein kinase superfamily. | 0.999 |
| LOC111233015 | chek2 | ENSSDUP00000028226 | ENSSDUP00000026192 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Checkpoint kinase 2. | 0.999 |
| LOC111233015 | mdm2 | ENSSDUP00000028226 | ENSSDUP00000024048 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | MDM2 proto-oncogene. | 0.999 |
| LOC111233015 | mdm4 | ENSSDUP00000028226 | ENSSDUP00000002400 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. | 0.999 |
| LOC111233015 | rps27a | ENSSDUP00000028226 | ENSSDUP00000004225 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Ribosomal protein S27a. | 0.988 |
| LOC111233015 | tp73 | ENSSDUP00000028226 | ENSSDUP00000001976 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.929 |
| LOC111233015 | yap1 | ENSSDUP00000028226 | ENSSDUP00000026252 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Yes-associated protein 1. | 0.582 |
| LOC111233556 | LOC111230695 | ENSSDUP00000023022 | ENSSDUP00000019843 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase. | 0.900 |
| LOC111233556 | LOC111233015 | ENSSDUP00000023022 | ENSSDUP00000028226 | E3 ubiquitin-protein ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.848 |
| LOC111233556 | mdm2 | ENSSDUP00000023022 | ENSSDUP00000024048 | E3 ubiquitin-protein ligase. | MDM2 proto-oncogene. | 0.635 |
| LOC111233556 | rps27a | ENSSDUP00000023022 | ENSSDUP00000004225 | E3 ubiquitin-protein ligase. | Ribosomal protein S27a. | 0.912 |
