close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD3SET and MYND domain containing 3. (438 aa)    
Predicted Functional Partners:
LOC111233015
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.874
map3k2
Mitogen-activated protein kinase kinase kinase 2.
   
 
 0.762
ash2l
Ash2 like, histone lysine methyltransferase complex subunit.
    
 0.700
plod1
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a.
   
 0.689
LOC111239991
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3.
   
 0.689
plod2
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2.
   
 0.689
rbbp5
Retinoblastoma binding protein 5.
    
 0.675
LOC111221016
Mitogen-activated protein kinase kinase kinase 22.
   
 
 0.659
map3k3
Mitogen-activated protein kinase kinase kinase 3.
   
 
 0.659
helz
Helicase with zinc finger.
    
 0.656
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.