RTEL1 protein (Seriola dumerili) - STRING interaction network

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RTEL1

Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1035 aa)

Predicted Functional Partners:

slf1

0.979

topbp1

0.946

ercc3

0.935

LOC111229339

0.932

bard1

0.930

gtf2h1

0.930

gtf2h4

0.929

mnat1

0.929

gtf2h3

0.929

brca1

0.927

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111229339	RTEL1	ENSSDUP00000013072	ENSSDUP00000002676	General transcription factor IIH subunit.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.932
LOC111229339	ercc3	ENSSDUP00000013072	ENSSDUP00000029414	General transcription factor IIH subunit.	Excision repair cross-complementation group 3.	0.999
LOC111229339	gtf2h1	ENSSDUP00000013072	ENSSDUP00000027242	General transcription factor IIH subunit.	General transcription factor IIH, polypeptide 1.	0.999
LOC111229339	gtf2h3	ENSSDUP00000013072	ENSSDUP00000028973	General transcription factor IIH subunit.	General transcription factor IIH, polypeptide 3.	0.999
LOC111229339	gtf2h4	ENSSDUP00000013072	ENSSDUP00000015669	General transcription factor IIH subunit.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.999
LOC111229339	mnat1	ENSSDUP00000013072	ENSSDUP00000026986	General transcription factor IIH subunit.	MNAT1 component of CDK activating kinase.	0.999
RTEL1	LOC111229339	ENSSDUP00000002676	ENSSDUP00000013072	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	General transcription factor IIH subunit.	0.932
RTEL1	bard1	ENSSDUP00000002676	ENSSDUP00000019914	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	BRCA1 associated RING domain 1.	0.930
RTEL1	brca1	ENSSDUP00000002676	ENSSDUP00000029899	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Uncharacterized protein.	0.927
RTEL1	ercc3	ENSSDUP00000002676	ENSSDUP00000029414	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Excision repair cross-complementation group 3.	0.935
RTEL1	gtf2h1	ENSSDUP00000002676	ENSSDUP00000027242	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	General transcription factor IIH, polypeptide 1.	0.930
RTEL1	gtf2h3	ENSSDUP00000002676	ENSSDUP00000028973	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	General transcription factor IIH, polypeptide 3.	0.929
RTEL1	gtf2h4	ENSSDUP00000002676	ENSSDUP00000015669	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.929
RTEL1	mnat1	ENSSDUP00000002676	ENSSDUP00000026986	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	MNAT1 component of CDK activating kinase.	0.929
RTEL1	slf1	ENSSDUP00000002676	ENSSDUP00000024520	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	SMC5-SMC6 complex localization factor 1.	0.979
RTEL1	topbp1	ENSSDUP00000002676	ENSSDUP00000014300	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	DNA topoisomerase II binding protein 1.	0.946
bard1	RTEL1	ENSSDUP00000019914	ENSSDUP00000002676	BRCA1 associated RING domain 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.930
bard1	brca1	ENSSDUP00000019914	ENSSDUP00000029899	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.999
bard1	slf1	ENSSDUP00000019914	ENSSDUP00000024520	BRCA1 associated RING domain 1.	SMC5-SMC6 complex localization factor 1.	0.995
bard1	topbp1	ENSSDUP00000019914	ENSSDUP00000014300	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.977

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