LOC111221469 protein (Seriola dumerili) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC111221469

Dual specificity tyrosine phosphorylation regulated kinase 3. (604 aa)

Predicted Functional Partners:

LOC111233015

0.710

atm

0.656

DCAF7

0.598

LOC111220197

0.598

mdm2

0.534

fbxw11

0.510

mdm4

0.450

rps27a

0.447

DCAF1

0.441

LOC111219492

0.441

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCAF1	LOC111221469	ENSSDUP00000021181	ENSSDUP00000002953	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.441
DCAF7	LOC111221469	ENSSDUP00000030781	ENSSDUP00000002953	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.598
LOC111219492	LOC111221469	ENSSDUP00000023860	ENSSDUP00000002953	LisH domain-containing protein.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.441
LOC111220197	LOC111221469	ENSSDUP00000031842	ENSSDUP00000002953	WD_REPEATS_REGION domain-containing protein.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.598
LOC111221469	DCAF1	ENSSDUP00000002953	ENSSDUP00000021181	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 1.	0.441
LOC111221469	DCAF7	ENSSDUP00000002953	ENSSDUP00000030781	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 7.	0.598
LOC111221469	LOC111219492	ENSSDUP00000002953	ENSSDUP00000023860	Dual specificity tyrosine phosphorylation regulated kinase 3.	LisH domain-containing protein.	0.441
LOC111221469	LOC111220197	ENSSDUP00000002953	ENSSDUP00000031842	Dual specificity tyrosine phosphorylation regulated kinase 3.	WD_REPEATS_REGION domain-containing protein.	0.598
LOC111221469	LOC111233015	ENSSDUP00000002953	ENSSDUP00000028226	Dual specificity tyrosine phosphorylation regulated kinase 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.710
LOC111221469	atm	ENSSDUP00000002953	ENSSDUP00000015925	Dual specificity tyrosine phosphorylation regulated kinase 3.	Non-specific serine/threonine protein kinase.	0.656
LOC111221469	fbxw11	ENSSDUP00000002953	ENSSDUP00000031999	Dual specificity tyrosine phosphorylation regulated kinase 3.	F-box and WD repeat domain containing 11b.	0.510
LOC111221469	mdm2	ENSSDUP00000002953	ENSSDUP00000024048	Dual specificity tyrosine phosphorylation regulated kinase 3.	MDM2 proto-oncogene.	0.534
LOC111221469	mdm4	ENSSDUP00000002953	ENSSDUP00000002400	Dual specificity tyrosine phosphorylation regulated kinase 3.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.450
LOC111221469	rps27a	ENSSDUP00000002953	ENSSDUP00000004225	Dual specificity tyrosine phosphorylation regulated kinase 3.	Ribosomal protein S27a.	0.447
LOC111233015	LOC111221469	ENSSDUP00000028226	ENSSDUP00000002953	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.710
LOC111233015	atm	ENSSDUP00000028226	ENSSDUP00000015925	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Non-specific serine/threonine protein kinase.	0.998
LOC111233015	mdm2	ENSSDUP00000028226	ENSSDUP00000024048	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM2 proto-oncogene.	0.999
LOC111233015	mdm4	ENSSDUP00000028226	ENSSDUP00000002400	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.999
LOC111233015	rps27a	ENSSDUP00000028226	ENSSDUP00000004225	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ribosomal protein S27a.	0.938
atm	LOC111221469	ENSSDUP00000015925	ENSSDUP00000002953	Non-specific serine/threonine protein kinase.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.656