STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC111234336Transmembrane phosphatase with tensin homology. (510 aa)    
Predicted Functional Partners:
sprtn
SprT-like N-terminal domain.
   
    0.771
usp7
Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.
   
 0.761
LOC111233015
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.683
usp40
Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family.
   
 0.657
otud3
OTU deubiquitinase 3.
    
 0.642
frk
Tyrosine-protein kinase.
    
 0.637
gak
Cyclin G associated kinase.
   
0.626
nedd4l
NEDD4 like E3 ubiquitin protein ligase.
    
 0.581
nedd4
E3 ubiquitin-protein ligase.
    
 0.581
xiap
X-linked inhibitor of apoptosis.
   
 0.575
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
Server load: low (22%) [HD]