ARHGAP6 protein (Seriola dumerili) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ARHGAP6

Rho GTPase activating protein 6. (793 aa)

Predicted Functional Partners:

aspm

0.624

kif11

0.616

rhot2

0.576

ttk

0.567

espl1

0.528

ndc80

0.520

LOC111219966

0.505

cog3

0.499

anks3

0.497

rhbdl1

0.495

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP6	LOC111219966	ENSSDUP00000004198	ENSSDUP00000030786	Rho GTPase activating protein 6.	Centrosomal protein 55 like.	0.505
ARHGAP6	anks3	ENSSDUP00000004198	ENSSDUP00000002965	Rho GTPase activating protein 6.	Ankyrin repeat and sterile alpha motif domain containing 3.	0.497
ARHGAP6	aspm	ENSSDUP00000004198	ENSSDUP00000023450	Rho GTPase activating protein 6.	Abnormal spindle microtubule assembly.	0.624
ARHGAP6	cog3	ENSSDUP00000004198	ENSSDUP00000003966	Rho GTPase activating protein 6.	Component of oligomeric golgi complex 3.	0.499
ARHGAP6	espl1	ENSSDUP00000004198	ENSSDUP00000009153	Rho GTPase activating protein 6.	Extra spindle pole bodies like 1, separase.	0.528
ARHGAP6	kif11	ENSSDUP00000004198	ENSSDUP00000007453	Rho GTPase activating protein 6.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.616
ARHGAP6	ndc80	ENSSDUP00000004198	ENSSDUP00000030427	Rho GTPase activating protein 6.	NDC80 kinetochore complex component.	0.520
ARHGAP6	rhbdl1	ENSSDUP00000004198	ENSSDUP00000002829	Rho GTPase activating protein 6.	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.495
ARHGAP6	rhot2	ENSSDUP00000004198	ENSSDUP00000002749	Rho GTPase activating protein 6.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.576
ARHGAP6	ttk	ENSSDUP00000004198	ENSSDUP00000012823	Rho GTPase activating protein 6.	Ttk protein kinase.	0.567
LOC111219966	ARHGAP6	ENSSDUP00000030786	ENSSDUP00000004198	Centrosomal protein 55 like.	Rho GTPase activating protein 6.	0.505
LOC111219966	aspm	ENSSDUP00000030786	ENSSDUP00000023450	Centrosomal protein 55 like.	Abnormal spindle microtubule assembly.	0.889
LOC111219966	espl1	ENSSDUP00000030786	ENSSDUP00000009153	Centrosomal protein 55 like.	Extra spindle pole bodies like 1, separase.	0.706
LOC111219966	kif11	ENSSDUP00000030786	ENSSDUP00000007453	Centrosomal protein 55 like.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.940
LOC111219966	ndc80	ENSSDUP00000030786	ENSSDUP00000030427	Centrosomal protein 55 like.	NDC80 kinetochore complex component.	0.883
LOC111219966	ttk	ENSSDUP00000030786	ENSSDUP00000012823	Centrosomal protein 55 like.	Ttk protein kinase.	0.925
anks3	ARHGAP6	ENSSDUP00000002965	ENSSDUP00000004198	Ankyrin repeat and sterile alpha motif domain containing 3.	Rho GTPase activating protein 6.	0.497
anks3	cog3	ENSSDUP00000002965	ENSSDUP00000003966	Ankyrin repeat and sterile alpha motif domain containing 3.	Component of oligomeric golgi complex 3.	0.564
anks3	rhbdl1	ENSSDUP00000002965	ENSSDUP00000002829	Ankyrin repeat and sterile alpha motif domain containing 3.	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.533
anks3	rhot2	ENSSDUP00000002965	ENSSDUP00000002749	Ankyrin repeat and sterile alpha motif domain containing 3.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.586

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.946

expected number of edges:

17

PPI enrichment p-value:

1.45e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

3 of 17

1.72

0.93

0.0135

GO:0010467

Gene expression

7 of 206

1.0

0.82

0.0016

GO:0009059

Macromolecule biosynthetic process

7 of 209

1.0

0.81

0.0016

GO:0044271

Cellular nitrogen compound biosynthetic process

7 of 362

0.76

0.5

0.0135

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 6

2.17

1.61

0.00084

GO:0019843

rRNA binding

4 of 41

1.46

1.2

0.0014

GO:0003735

Structural constituent of ribosome

4 of 57

1.32

0.97

0.0039

GO:0003676

Nucleic acid binding

9 of 361

0.87

0.81

9.00e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 7

2.1

1.73

0.00042

GO:0015935

Small ribosomal subunit

2 of 6

1.99

1.19

0.0051

GO:0005840

Ribosome

4 of 60

1.29

1.06

0.0017

GO:0032991

Protein-containing complex

5 of 200

0.87

0.63

0.0051

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34702846

(2021) MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes.

2 of 25

1.37

0.63

0.0450

PMID:37041201

(2023) Anaerobic thiosulfate oxidation by the Roseobacter group is prevalent in marine biofilms.

2 of 34

1.24

0.6

0.0450

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:217

RNA polymerase

3 of 5

2.25

2.06

0.00011

CL:5015

Mixed, incl. ArsC family, and Cold-shock protein, DNA-binding

3 of 6

2.17

1.97

0.00015

CL:80

Ribosome, and Translation regulator activity

7 of 74

1.45

1.96

1.05e-06

CL:131

Mixed, incl. Small ribosomal subunit, and K Homology domain, type 2

3 of 9

1.99

1.72

0.00036

CL:92

Ribosome

4 of 54

1.34

1.12

0.0014

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

otm03020

RNA polymerase

3 of 4

2.35

2.09

0.00011

otm03010

Ribosome

4 of 54

1.34

1.11

0.0015

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

3 of 22

1.61

0.85

0.0179

GOCC:0044391

Ribosomal subunit

3 of 26

1.53

0.83

0.0179

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 10

1.77

0.8

0.0272

GOCC:0000428

DNA-directed RNA polymerase complex

3 of 42

1.32

0.71

0.0266

GOCC:0032991

Protein-containing complex

6 of 450

0.6

0.35

0.0461

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 5

2.25

1.83

0.00033

KW-0689

Ribosomal protein

4 of 56

1.32

1.0

0.0032

KW-0699

rRNA-binding

3 of 38

1.37

0.83

0.0136

KW-0548

Nucleotidyltransferase

3 of 37

1.38

0.83

0.0136

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012340

Nucleic acid-binding, OB-fold

4 of 30

1.6

1.12

0.0040

IPR002059

Cold-shock protein, DNA-binding

2 of 2

2.47

0.77

0.0403

IPR011129

Cold shock domain

2 of 3

2.29

0.74

0.0446

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00357

Cold shock protein domain

2 of 3

2.29

1.06

0.0109

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