rgs14 protein (Seriola dumerili) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

rgs14

Regulator of G protein signaling 14a. (610 aa)

Predicted Functional Partners:

ENSSDUP00000002335

0.902

apc2

0.552

ENSSDUP00000030486

0.552

csnk1a1

0.517

LOC111218977

0.508

LOC111222886

0.508

gsk3b

0.506

LOC111220843

0.506

LOC111230141

0.506

ENSSDUP00000032333

0.481

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000002335	ENSSDUP00000030486	ENSSDUP00000002335	ENSSDUP00000030486	Regulator of G protein signaling 12b.	APC_N_CC domain-containing protein.	0.552
ENSSDUP00000002335	LOC111218977	ENSSDUP00000002335	ENSSDUP00000011575	Regulator of G protein signaling 12b.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.508
ENSSDUP00000002335	LOC111220843	ENSSDUP00000002335	ENSSDUP00000013472	Regulator of G protein signaling 12b.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.506
ENSSDUP00000002335	LOC111222886	ENSSDUP00000002335	ENSSDUP00000029043	Regulator of G protein signaling 12b.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.508
ENSSDUP00000002335	LOC111230141	ENSSDUP00000002335	ENSSDUP00000020056	Regulator of G protein signaling 12b.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.506
ENSSDUP00000002335	apc2	ENSSDUP00000002335	ENSSDUP00000029017	Regulator of G protein signaling 12b.	APC regulator of WNT signaling pathway 2.	0.552
ENSSDUP00000002335	csnk1a1	ENSSDUP00000002335	ENSSDUP00000000647	Regulator of G protein signaling 12b.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.517
ENSSDUP00000002335	gsk3b	ENSSDUP00000002335	ENSSDUP00000006189	Regulator of G protein signaling 12b.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.506
ENSSDUP00000002335	rgs14	ENSSDUP00000002335	ENSSDUP00000005368	Regulator of G protein signaling 12b.	Regulator of G protein signaling 14a.	0.902
ENSSDUP00000030486	ENSSDUP00000002335	ENSSDUP00000030486	ENSSDUP00000002335	APC_N_CC domain-containing protein.	Regulator of G protein signaling 12b.	0.552
ENSSDUP00000030486	LOC111220843	ENSSDUP00000030486	ENSSDUP00000013472	APC_N_CC domain-containing protein.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.825
ENSSDUP00000030486	LOC111230141	ENSSDUP00000030486	ENSSDUP00000020056	APC_N_CC domain-containing protein.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.825
ENSSDUP00000030486	csnk1a1	ENSSDUP00000030486	ENSSDUP00000000647	APC_N_CC domain-containing protein.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.772
ENSSDUP00000030486	gsk3b	ENSSDUP00000030486	ENSSDUP00000006189	APC_N_CC domain-containing protein.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.825
ENSSDUP00000030486	rgs14	ENSSDUP00000030486	ENSSDUP00000005368	APC_N_CC domain-containing protein.	Regulator of G protein signaling 14a.	0.552
ENSSDUP00000032333	rgs14	ENSSDUP00000032333	ENSSDUP00000005368	Carbonic anhydrase XVb; Belongs to the alpha-carbonic anhydrase family.	Regulator of G protein signaling 14a.	0.481
LOC111218977	ENSSDUP00000002335	ENSSDUP00000011575	ENSSDUP00000002335	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Regulator of G protein signaling 12b.	0.508
LOC111218977	LOC111222886	ENSSDUP00000011575	ENSSDUP00000029043	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.934
LOC111218977	rgs14	ENSSDUP00000011575	ENSSDUP00000005368	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	Regulator of G protein signaling 14a.	0.508
LOC111220843	ENSSDUP00000002335	ENSSDUP00000013472	ENSSDUP00000002335	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	Regulator of G protein signaling 12b.	0.506

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.745

expected number of edges:

28

PPI enrichment p-value:

0.147

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990544

Mitochondrial ATP transmembrane transport

3 of 4

3.09

2.28

7.36e-05

GO:0140021

Mitochondrial ADP transmembrane transport

3 of 4

3.09

2.28

7.36e-05

GO:1901029

Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

3 of 11

2.65

2.02

0.00019

GO:1901526

Positive regulation of mitophagy

2 of 9

2.56

1.06

0.0116

GO:1990845

Adaptive thermogenesis

2 of 21

2.19

0.8

0.0340

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005471

ATP:ADP antiporter activity

3 of 4

3.09

2.6

1.90e-05

GO:0017077

Oxidative phosphorylation uncoupler activity

2 of 5

2.82

1.51

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005757

Mitochondrial permeability transition pore complex

3 of 10

2.69

2.22

8.08e-05

GO:0005815

Microtubule organizing center

6 of 749

1.12

0.96

0.0010

GO:0015630

Microtubule cytoskeleton

7 of 1238

0.97

0.81

0.0010

GO:0005814

Centriole

3 of 145

1.53

0.81

0.0204

GO:0005740

Mitochondrial envelope

5 of 641

1.11

0.77

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13605

Mitochondrial permeability transition pore complex, and TspO/MBR-related protein

3 of 13

2.58

1.87

0.00036

CL:12648

Post-chaperonin tubulin folding pathway, and Trafficking of myristoylated proteins to the cilium

3 of 13

2.58

1.87

0.00036

CL:13609

Mitochondrial permeability transition pore complex, and Porin, eukaryotic type

2 of 7

2.67

1.16

0.0078

CL:2389

Mixed, incl. Axonemal microtubule, and Tubulin/FtsZ, 2-layer sandwich domain

3 of 103

1.68

0.88

0.0172

CL:2422

Axonemal microtubule, and DM10 domain

2 of 22

2.17

0.84

0.0272

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

3 of 140

1.55

0.77

0.0265

map05017

Spinocerebellar ataxia

3 of 155

1.5

0.76

0.0265

map04218

Cellular senescence

3 of 188

1.42

0.74

0.0265

map04217

Necroptosis

3 of 180

1.44

0.74

0.0265

map04022

cGMP-PKG signaling pathway

3 of 179

1.44

0.74

0.0265

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-83936

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

5 of 13

2.8

4.99

4.15e-10

MAP-425397

Transport of vitamins, nucleosides, and related molecules

5 of 52

2.2

3.41

1.00e-07

MAP-425407

SLC-mediated transmembrane transport

5 of 309

1.43

1.35

0.00037

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005757

Mitochondrial permeability transition pore complex

3 of 5

2.99

2.61

1.79e-05

GOCC:0005740

Mitochondrial envelope

5 of 418

1.29

1.05

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00153

Mitochondrial carrier protein

3 of 51

1.99

1.08

0.0086

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007714

CFA20 domain

3 of 3

3.22

2.57

2.25e-05

IPR002113

ADP/ATP carrier protein, eukaryotic type

3 of 3

3.22

2.57

2.25e-05

IPR002067

Mitochondrial carrier protein

3 of 27

2.26

1.5

0.0015

IPR044612

ADP-ribosylation factor-like protein 2/3

2 of 2

3.22

1.37

0.0034

IPR040441

Cilia- and flagella-associated protein 20/CFAP20DC

2 of 2

3.22

1.37

0.0034

(more ...)

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