ENSSDUP00000006441 protein (Seriola dumerili)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

ENSSDUP00000006441

Link domain-containing protein. (268 aa)

Predicted Functional Partners:

LOC111228646

0.542

itpr3

0.515

LOC111221798

0.515

LOC111221456

0.515

itpr2

0.515

chp1

0.512

LOC111224291

0.493

LOC111235208

0.493

LOC111220349

0.493

ENSSDUP00000022015

0.493

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000006441	ENSSDUP00000022015	ENSSDUP00000006441	ENSSDUP00000022015	Link domain-containing protein.	Si:dkey-121j17.5; Belongs to the protein kinase superfamily.	0.493
ENSSDUP00000006441	LOC111220349	ENSSDUP00000006441	ENSSDUP00000019222	Link domain-containing protein.	cGMP-dependent protein kinase.	0.493
ENSSDUP00000006441	LOC111221456	ENSSDUP00000006441	ENSSDUP00000017079	Link domain-containing protein.	Inositol 1,4,5-trisphosphate receptor, type 1b.	0.515
ENSSDUP00000006441	LOC111221798	ENSSDUP00000006441	ENSSDUP00000008489	Link domain-containing protein.	Inositol 1,4,5-trisphosphate receptor, type 1a.	0.515
ENSSDUP00000006441	LOC111224291	ENSSDUP00000006441	ENSSDUP00000008451	Link domain-containing protein.	Uncharacterized protein.	0.493
ENSSDUP00000006441	LOC111228646	ENSSDUP00000006441	ENSSDUP00000023530	Link domain-containing protein.	Link domain-containing protein.	0.542
ENSSDUP00000006441	LOC111235208	ENSSDUP00000006441	ENSSDUP00000018213	Link domain-containing protein.	cGMP-dependent protein kinase.	0.493
ENSSDUP00000006441	chp1	ENSSDUP00000006441	ENSSDUP00000025454	Link domain-containing protein.	Calcineurin-like EF-hand protein 1.	0.512
ENSSDUP00000006441	itpr2	ENSSDUP00000006441	ENSSDUP00000024730	Link domain-containing protein.	Inositol 1,4,5-trisphosphate receptor, type 2.	0.515
ENSSDUP00000006441	itpr3	ENSSDUP00000006441	ENSSDUP00000000987	Link domain-containing protein.	Inositol 1,4,5-trisphosphate receptor, type 3.	0.515
ENSSDUP00000022015	ENSSDUP00000006441	ENSSDUP00000022015	ENSSDUP00000006441	Si:dkey-121j17.5; Belongs to the protein kinase superfamily.	Link domain-containing protein.	0.493
ENSSDUP00000022015	LOC111235208	ENSSDUP00000022015	ENSSDUP00000018213	Si:dkey-121j17.5; Belongs to the protein kinase superfamily.	cGMP-dependent protein kinase.	0.900
LOC111220349	ENSSDUP00000006441	ENSSDUP00000019222	ENSSDUP00000006441	cGMP-dependent protein kinase.	Link domain-containing protein.	0.493
LOC111221456	ENSSDUP00000006441	ENSSDUP00000017079	ENSSDUP00000006441	Inositol 1,4,5-trisphosphate receptor, type 1b.	Link domain-containing protein.	0.515
LOC111221456	LOC111221798	ENSSDUP00000017079	ENSSDUP00000008489	Inositol 1,4,5-trisphosphate receptor, type 1b.	Inositol 1,4,5-trisphosphate receptor, type 1a.	0.900
LOC111221798	ENSSDUP00000006441	ENSSDUP00000008489	ENSSDUP00000006441	Inositol 1,4,5-trisphosphate receptor, type 1a.	Link domain-containing protein.	0.515
LOC111221798	LOC111221456	ENSSDUP00000008489	ENSSDUP00000017079	Inositol 1,4,5-trisphosphate receptor, type 1a.	Inositol 1,4,5-trisphosphate receptor, type 1b.	0.900
LOC111224291	ENSSDUP00000006441	ENSSDUP00000008451	ENSSDUP00000006441	Uncharacterized protein.	Link domain-containing protein.	0.493
LOC111228646	ENSSDUP00000006441	ENSSDUP00000023530	ENSSDUP00000006441	Link domain-containing protein.	Link domain-containing protein.	0.542
LOC111235208	ENSSDUP00000006441	ENSSDUP00000018213	ENSSDUP00000006441	cGMP-dependent protein kinase.	Link domain-containing protein.	0.493

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.874

expected number of edges:

11

PPI enrichment p-value:

2e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009147

Pyrimidine nucleoside triphosphate metabolic process

4 of 10

2.08

2.39

1.47e-05

GO:0009141

Nucleoside triphosphate metabolic process

6 of 42

1.64

2.17

3.19e-06

GO:0009394

2-deoxyribonucleotide metabolic process

3 of 6

2.18

1.96

0.00016

GO:0009200

Deoxyribonucleoside triphosphate metabolic process

3 of 6

2.18

1.96

0.00016

GO:0006221

Pyrimidine nucleotide biosynthetic process

4 of 19

1.81

1.89

7.84e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005525

GTP binding

3 of 34

1.43

0.75

0.0253

GO:0000287

Magnesium ion binding

4 of 74

1.21

0.74

0.0156

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

2 of 14

1.64

0.71

0.0396

GO:0016810

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

3 of 50

1.26

0.64

0.0370

GO:0046872

Metal ion binding

8 of 385

0.8

0.62

0.0026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3049

Mixed, incl. Oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor, and dUTPase

3 of 12

1.88

1.05

0.0090

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pbo00240

Pyrimidine metabolism

5 of 27

1.75

2.35

2.56e-06

pbo00230

Purine metabolism

5 of 47

1.51

1.8

1.60e-05

pbo00790

Folate biosynthesis

2 of 18

1.53

0.66

0.0452

pbo01100

Metabolic pathways

10 of 638

0.68

0.62

2.12e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0546

Nucleotide metabolism

3 of 5

2.26

1.86

0.00029

KW-0460

Magnesium

4 of 103

1.07

0.64

0.0210

KW-0479

Metal-binding

5 of 226

0.83

0.5

0.0244

KW-0547

Nucleotide-binding

6 of 311

0.77

0.48

0.0210

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00692

dUTPase

2 of 2

2.48

0.84

0.0297

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00471

Metal dependent phosphohydrolases with conserved HD motif.

2 of 6

2.0

0.8

0.0313

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