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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (512 aa)    
Predicted Functional Partners:
LOC111236845
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.920
LOC111230214
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.920
LOC111239520
Uncharacterized protein.
  
  
 
0.903
nab2
NGFI-A binding protein 2 (EGR1 binding protein 2).
   
 0.726
egr2
Early growth response 2b.
  
 
0.715
ENSSDUP00000020655
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
   
 0.670
LOC111239160
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
   
 0.670
ENSSDUP00000000930
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
   
 0.627
nab1
NGFI-A binding protein 1a (EGR1 binding protein 1).
    
 0.625
fosb
FBJ murine osteosarcoma viral oncogene homolog B.
   
 0.612
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
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