LOC111224335 protein (Seriola dumerili) - STRING interaction network

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC111224335

Retinol dehydrogenase 12, like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa)

Predicted Functional Partners:

LOC111237093

0.923

LOC111238623

0.918

pnpla4

0.913

LOC111232312

0.908

LOC111232447

0.908

aldh1a3

0.751

aldh1a2

0.751

ALDH1A1

0.751

LOC111223679

0.709

LOC111220358

0.709

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A1	LOC111220358	ENSSDUP00000029873	ENSSDUP00000017529	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Si:ch1073-13h15.3.	0.422
ALDH1A1	LOC111223679	ENSSDUP00000029873	ENSSDUP00000008953	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Amino_oxidase domain-containing protein.	0.422
ALDH1A1	LOC111224335	ENSSDUP00000029873	ENSSDUP00000010523	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 12, like; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.751
ALDH1A1	LOC111232312	ENSSDUP00000029873	ENSSDUP00000018610	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Aldehyde oxidase 5.	0.921
ALDH1A1	LOC111232447	ENSSDUP00000029873	ENSSDUP00000020812	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Aldehyde oxidase 6.	0.921
ALDH1A1	LOC111237093	ENSSDUP00000029873	ENSSDUP00000022870	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.	0.945
ALDH1A1	aldh1a2	ENSSDUP00000029873	ENSSDUP00000025158	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family.	0.901
ALDH1A1	aldh1a3	ENSSDUP00000029873	ENSSDUP00000016564	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase 1 family, member A3; Belongs to the aldehyde dehydrogenase family.	0.901
LOC111220358	ALDH1A1	ENSSDUP00000017529	ENSSDUP00000029873	Si:ch1073-13h15.3.	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	0.422
LOC111220358	LOC111223679	ENSSDUP00000017529	ENSSDUP00000008953	Si:ch1073-13h15.3.	Amino_oxidase domain-containing protein.	0.901
LOC111220358	LOC111224335	ENSSDUP00000017529	ENSSDUP00000010523	Si:ch1073-13h15.3.	Retinol dehydrogenase 12, like; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.709
LOC111220358	LOC111237093	ENSSDUP00000017529	ENSSDUP00000022870	Si:ch1073-13h15.3.	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.	0.910
LOC111220358	LOC111238623	ENSSDUP00000017529	ENSSDUP00000029433	Si:ch1073-13h15.3.	Cytochrome P450, family 27, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.907
LOC111220358	aldh1a2	ENSSDUP00000017529	ENSSDUP00000025158	Si:ch1073-13h15.3.	Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family.	0.422
LOC111220358	aldh1a3	ENSSDUP00000017529	ENSSDUP00000016564	Si:ch1073-13h15.3.	Aldehyde dehydrogenase 1 family, member A3; Belongs to the aldehyde dehydrogenase family.	0.422
LOC111220358	pnpla4	ENSSDUP00000017529	ENSSDUP00000027842	Si:ch1073-13h15.3.	PNPLA domain-containing protein.	0.900
LOC111223679	ALDH1A1	ENSSDUP00000008953	ENSSDUP00000029873	Amino_oxidase domain-containing protein.	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	0.422
LOC111223679	LOC111220358	ENSSDUP00000008953	ENSSDUP00000017529	Amino_oxidase domain-containing protein.	Si:ch1073-13h15.3.	0.901
LOC111223679	LOC111224335	ENSSDUP00000008953	ENSSDUP00000010523	Amino_oxidase domain-containing protein.	Retinol dehydrogenase 12, like; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.709
LOC111223679	LOC111237093	ENSSDUP00000008953	ENSSDUP00000022870	Amino_oxidase domain-containing protein.	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.	0.910

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

16

PPI enrichment p-value:

5.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

9 of 110

1.51

2.68

4.74e-10

GO:0044718

Siderophore transmembrane transport

3 of 20

1.77

1.29

0.0023

GO:0055085

Transmembrane transport

8 of 414

0.88

0.81

0.00015

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

3 of 4

2.47

2.12

0.00011

GO:0015343

Siderophore transmembrane transporter activity

3 of 28

1.63

0.97

0.0100

GO:0022857

Transmembrane transporter activity

9 of 432

0.92

0.9

3.60e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030288

Outer membrane-bounded periplasmic space

3 of 44

1.43

1.03

0.0042

GO:0005886

Plasma membrane

9 of 653

0.74

0.64

0.00023

GO:0016021

Integral component of membrane

9 of 967

0.57

0.44

0.0022

GO:0016020

Membrane

10 of 1384

0.46

0.37

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5771

Mixed, incl. TonB, C-terminal, and MotA/TolQ/ExbB proton channel

9 of 20

2.25

6.96

6.73e-17

CL:5772

Mixed, incl. MotA/TolQ/ExbB proton channel, and Energy transducer activity

7 of 13

2.33

5.82

3.74e-13

CL:5763

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

11 of 63

1.84

5.22

1.49e-17

CL:5764

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

10 of 56

1.85

5.01

4.05e-16

CL:5786

Mixed, incl. Putative MotA/TolQ/ExbB family protein, and Energy transducer activity

5 of 6

2.52

4.56

1.30e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01503

Cationic antimicrobial peptide (CAMP) resistance

5 of 88

1.35

1.33

0.00022

map02010

ABC transporters

5 of 166

1.08

0.86

0.0022

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

9 of 45

1.9

4.8

4.36e-14

KW-0735

Signal-anchor

3 of 5

2.38

2.25

5.28e-05

KW-0997

Cell inner membrane

3 of 81

1.17

0.59

0.0404

KW-0812

Transmembrane

9 of 949

0.57

0.44

0.0024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02472

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.82

2.91e-08

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 7

2.23

1.75

0.00046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003400

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.63

7.46e-08

IPR003538

Gram-negative bacterial TonB protein

3 of 4

2.47

1.86

0.00035

IPR037682

TonB, C-terminal

3 of 7

2.23

1.63

0.00079

IPR006260

TonB/TolA, C-terminal

3 of 7

2.23

1.63

0.00079

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