node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSSDUP00000016923 | ENSSDUP00000016964 | ENSSDUP00000016923 | ENSSDUP00000016964 | PHD-type domain-containing protein. | Lysine (K)-specific demethylase 4A, genome duplicate b. | 0.899 |
ENSSDUP00000016923 | LOC111231525 | ENSSDUP00000016923 | ENSSDUP00000005205 | PHD-type domain-containing protein. | Uncharacterized protein. | 0.899 |
ENSSDUP00000016923 | atm | ENSSDUP00000016923 | ENSSDUP00000015925 | PHD-type domain-containing protein. | Non-specific serine/threonine protein kinase. | 0.467 |
ENSSDUP00000016923 | kdm1a | ENSSDUP00000016923 | ENSSDUP00000022218 | PHD-type domain-containing protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.579 |
ENSSDUP00000016923 | rnf8 | ENSSDUP00000016923 | ENSSDUP00000004993 | PHD-type domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.441 |
ENSSDUP00000016923 | tp53bp1 | ENSSDUP00000016923 | ENSSDUP00000026700 | PHD-type domain-containing protein. | Tumor protein p53 binding protein, 1. | 0.451 |
ENSSDUP00000016923 | znf217 | ENSSDUP00000016923 | ENSSDUP00000006239 | PHD-type domain-containing protein. | Zinc finger protein 217. | 0.424 |
ENSSDUP00000016964 | ENSSDUP00000016923 | ENSSDUP00000016964 | ENSSDUP00000016923 | Lysine (K)-specific demethylase 4A, genome duplicate b. | PHD-type domain-containing protein. | 0.899 |
ENSSDUP00000016964 | atm | ENSSDUP00000016964 | ENSSDUP00000015925 | Lysine (K)-specific demethylase 4A, genome duplicate b. | Non-specific serine/threonine protein kinase. | 0.467 |
ENSSDUP00000016964 | kdm1a | ENSSDUP00000016964 | ENSSDUP00000022218 | Lysine (K)-specific demethylase 4A, genome duplicate b. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.579 |
ENSSDUP00000016964 | rnf8 | ENSSDUP00000016964 | ENSSDUP00000004993 | Lysine (K)-specific demethylase 4A, genome duplicate b. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.441 |
ENSSDUP00000016964 | tp53bp1 | ENSSDUP00000016964 | ENSSDUP00000026700 | Lysine (K)-specific demethylase 4A, genome duplicate b. | Tumor protein p53 binding protein, 1. | 0.451 |
ENSSDUP00000016964 | znf217 | ENSSDUP00000016964 | ENSSDUP00000006239 | Lysine (K)-specific demethylase 4A, genome duplicate b. | Zinc finger protein 217. | 0.424 |
LOC111231525 | ENSSDUP00000016923 | ENSSDUP00000005205 | ENSSDUP00000016923 | Uncharacterized protein. | PHD-type domain-containing protein. | 0.899 |
LOC111231525 | atm | ENSSDUP00000005205 | ENSSDUP00000015925 | Uncharacterized protein. | Non-specific serine/threonine protein kinase. | 0.493 |
LOC111231525 | kdm1a | ENSSDUP00000005205 | ENSSDUP00000022218 | Uncharacterized protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.596 |
LOC111231525 | rnf8 | ENSSDUP00000005205 | ENSSDUP00000004993 | Uncharacterized protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.464 |
LOC111231525 | tp53bp1 | ENSSDUP00000005205 | ENSSDUP00000026700 | Uncharacterized protein. | Tumor protein p53 binding protein, 1. | 0.478 |
LOC111231525 | znf217 | ENSSDUP00000005205 | ENSSDUP00000006239 | Uncharacterized protein. | Zinc finger protein 217. | 0.446 |
atm | ENSSDUP00000016923 | ENSSDUP00000015925 | ENSSDUP00000016923 | Non-specific serine/threonine protein kinase. | PHD-type domain-containing protein. | 0.467 |