tchp protein (Seriola dumerili) - STRING interaction network

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Score

tchp

Trichoplein, keratin filament binding. (499 aa)

Predicted Functional Partners:

mdm2

0.663

LOC111233015

0.603

mdm4

0.542

ctnnb1

0.494

Tmem251

0.424

pwwp2b

0.420

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111233015	ctnnb1	ENSSDUP00000028226	ENSSDUP00000016896	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Catenin (cadherin-associated protein), beta 1.	0.606
LOC111233015	mdm2	ENSSDUP00000028226	ENSSDUP00000024048	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM2 proto-oncogene.	0.999
LOC111233015	mdm4	ENSSDUP00000028226	ENSSDUP00000002400	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.999
LOC111233015	tchp	ENSSDUP00000028226	ENSSDUP00000017152	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Trichoplein, keratin filament binding.	0.603
Tmem251	pwwp2b	ENSSDUP00000023330	ENSSDUP00000028293	Transmembrane protein 251.	PWWP domain containing 2B.	0.641
Tmem251	tchp	ENSSDUP00000023330	ENSSDUP00000017152	Transmembrane protein 251.	Trichoplein, keratin filament binding.	0.424
ctnnb1	LOC111233015	ENSSDUP00000016896	ENSSDUP00000028226	Catenin (cadherin-associated protein), beta 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.606
ctnnb1	mdm2	ENSSDUP00000016896	ENSSDUP00000024048	Catenin (cadherin-associated protein), beta 1.	MDM2 proto-oncogene.	0.511
ctnnb1	tchp	ENSSDUP00000016896	ENSSDUP00000017152	Catenin (cadherin-associated protein), beta 1.	Trichoplein, keratin filament binding.	0.494
mdm2	LOC111233015	ENSSDUP00000024048	ENSSDUP00000028226	MDM2 proto-oncogene.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
mdm2	ctnnb1	ENSSDUP00000024048	ENSSDUP00000016896	MDM2 proto-oncogene.	Catenin (cadherin-associated protein), beta 1.	0.511
mdm2	mdm4	ENSSDUP00000024048	ENSSDUP00000002400	MDM2 proto-oncogene.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.999
mdm2	tchp	ENSSDUP00000024048	ENSSDUP00000017152	MDM2 proto-oncogene.	Trichoplein, keratin filament binding.	0.663
mdm4	LOC111233015	ENSSDUP00000002400	ENSSDUP00000028226	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
mdm4	mdm2	ENSSDUP00000002400	ENSSDUP00000024048	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	MDM2 proto-oncogene.	0.999
mdm4	tchp	ENSSDUP00000002400	ENSSDUP00000017152	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	Trichoplein, keratin filament binding.	0.542
pwwp2b	Tmem251	ENSSDUP00000028293	ENSSDUP00000023330	PWWP domain containing 2B.	Transmembrane protein 251.	0.641
pwwp2b	tchp	ENSSDUP00000028293	ENSSDUP00000017152	PWWP domain containing 2B.	Trichoplein, keratin filament binding.	0.420
tchp	LOC111233015	ENSSDUP00000017152	ENSSDUP00000028226	Trichoplein, keratin filament binding.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.603
tchp	Tmem251	ENSSDUP00000017152	ENSSDUP00000023330	Trichoplein, keratin filament binding.	Transmembrane protein 251.	0.424