Shank2 protein (Seriola dumerili) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Shank2

Uncharacterized protein. (120 aa)

Predicted Functional Partners:

ENSSDUP00000020182

0.903

ENSSDUP00000020145

0.837

dlgap3

0.801

LOC111237023

0.735

dlgap1

0.735

Dlgap2

0.735

LOC111217380

0.704

ENSSDUP00000031880

0.704

ENSSDUP00000031884

0.704

LOC111233284

0.701

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dlgap2	ENSSDUP00000020145	ENSSDUP00000015824	ENSSDUP00000020145	Discs, large (Drosophila) homolog-associated protein 2a.	PDZ domain-containing protein.	0.676
Dlgap2	ENSSDUP00000020182	ENSSDUP00000015824	ENSSDUP00000020182	Discs, large (Drosophila) homolog-associated protein 2a.	PDZ domain-containing protein.	0.633
Dlgap2	Shank2	ENSSDUP00000015824	ENSSDUP00000020160	Discs, large (Drosophila) homolog-associated protein 2a.	Uncharacterized protein.	0.735
Dlgap2	dlgap3	ENSSDUP00000015824	ENSSDUP00000004624	Discs, large (Drosophila) homolog-associated protein 2a.	Discs, large (Drosophila) homolog-associated protein 3.	0.461
ENSSDUP00000020145	Dlgap2	ENSSDUP00000020145	ENSSDUP00000015824	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 2a.	0.676
ENSSDUP00000020145	ENSSDUP00000031880	ENSSDUP00000020145	ENSSDUP00000031880	PDZ domain-containing protein.	Uncharacterized protein.	0.676
ENSSDUP00000020145	ENSSDUP00000031884	ENSSDUP00000020145	ENSSDUP00000031884	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 4b.	0.676
ENSSDUP00000020145	LOC111217380	ENSSDUP00000020145	ENSSDUP00000029563	PDZ domain-containing protein.	Uncharacterized protein.	0.676
ENSSDUP00000020145	LOC111233284	ENSSDUP00000020145	ENSSDUP00000005434	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 1a.	0.676
ENSSDUP00000020145	LOC111237023	ENSSDUP00000020145	ENSSDUP00000006204	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 2b.	0.676
ENSSDUP00000020145	Shank2	ENSSDUP00000020145	ENSSDUP00000020160	PDZ domain-containing protein.	Uncharacterized protein.	0.837
ENSSDUP00000020145	dlgap1	ENSSDUP00000020145	ENSSDUP00000009076	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 1b.	0.676
ENSSDUP00000020145	dlgap3	ENSSDUP00000020145	ENSSDUP00000004624	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 3.	0.676
ENSSDUP00000020182	Dlgap2	ENSSDUP00000020182	ENSSDUP00000015824	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 2a.	0.633
ENSSDUP00000020182	ENSSDUP00000031880	ENSSDUP00000020182	ENSSDUP00000031880	PDZ domain-containing protein.	Uncharacterized protein.	0.582
ENSSDUP00000020182	ENSSDUP00000031884	ENSSDUP00000020182	ENSSDUP00000031884	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 4b.	0.582
ENSSDUP00000020182	LOC111217380	ENSSDUP00000020182	ENSSDUP00000029563	PDZ domain-containing protein.	Uncharacterized protein.	0.582
ENSSDUP00000020182	LOC111233284	ENSSDUP00000020182	ENSSDUP00000005434	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 1a.	0.562
ENSSDUP00000020182	LOC111237023	ENSSDUP00000020182	ENSSDUP00000006204	PDZ domain-containing protein.	Discs, large (Drosophila) homolog-associated protein 2b.	0.633
ENSSDUP00000020182	Shank2	ENSSDUP00000020182	ENSSDUP00000020160	PDZ domain-containing protein.	Uncharacterized protein.	0.903

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.838

expected number of edges:

12

PPI enrichment p-value:

1.85e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

7 of 23

2.13

4.42

1.48e-10

GO:0007163

Establishment or maintenance of cell polarity

5 of 26

1.93

2.64

1.60e-06

GO:0022604

Regulation of cell morphogenesis

4 of 15

2.07

2.3

2.18e-05

GO:0030036

Actin cytoskeleton organization

5 of 49

1.65

1.94

2.18e-05

GO:0007165

Signal transduction

8 of 166

1.33

1.78

4.94e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

9 of 77

1.71

3.64

6.94e-12

GO:0005525

GTP binding

9 of 94

1.62

3.26

1.88e-11

GO:0019901

Protein kinase binding

3 of 24

1.74

1.36

0.0014

GO:0005509

Calcium ion binding

2 of 19

1.67

0.69

0.0438

GO:0043167

Ion binding

11 of 1226

0.6

0.53

2.75e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042995

Cell projection

4 of 31

1.75

1.73

0.00017

GO:0005886

Plasma membrane

8 of 186

1.28

1.67

6.01e-07

GO:0005938

Cell cortex

4 of 78

1.35

0.99

0.0041

GO:0005856

Cytoskeleton

4 of 150

1.07

0.59

0.0320

GO:0016020

Membrane

9 of 1063

0.57

0.42

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3834

Pleckstrin homology domain 5, and Small GTPase Rho

4 of 8

2.34

2.98

1.59e-06

CL:3831

Mixed, incl. Small GTPase mediated signal transduction, and Pleckstrin homology domain 5

5 of 22

2.0

2.85

7.39e-07

CL:3778

MAPK signaling pathway - yeast, and Small GTPase mediated signal transduction

6 of 50

1.72

2.48

7.21e-07

CL:4512

COPI vesicle coat, and ARF-like small GTPases

2 of 12

1.86

0.72

0.0421

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

wic04144

Endocytosis

4 of 59

1.47

1.27

0.00090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9012999

RHO GTPase cycle

8 of 99

1.55

2.66

2.94e-09

MAP-9716542

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

9 of 140

1.45

2.47

8.73e-10

MAP-194315

Signaling by Rho GTPases

8 of 136

1.41

2.17

2.21e-08

MAP-9696273

RND1 GTPase cycle

3 of 9

2.17

1.8

0.00033

MAP-9696270

RND2 GTPase cycle

2 of 2

2.64

1.31

0.0041

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

8 of 42

1.92

4.45

2.50e-12

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005225

Small GTP-binding protein domain

8 of 38

1.97

4.4

1.11e-11

IPR001806

Small GTPase

6 of 21

2.1

3.74

7.40e-09

IPR003578

Small GTPase Rho

4 of 4

2.64

3.36

4.95e-07

IPR027417

P-loop containing nucleoside triphosphate hydrolase

9 of 295

1.13

1.39

4.35e-07

IPR024156

Small GTPase superfamily, ARF type

2 of 4

2.34

0.85

0.0277

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

5 of 5

2.64

4.65

1.28e-09

SM00177

ARF-like small GTPases

2 of 4

2.34

1.12

0.0086

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