node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
coasy | eprs1 | ENSSDUP00000028969 | ENSSDUP00000012304 | CoA synthase. | Glutamyl-prolyl-tRNA synthetase. | 0.524 |
coasy | fpgs | ENSSDUP00000028969 | ENSSDUP00000025894 | CoA synthase. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.700 |
coasy | gart | ENSSDUP00000028969 | ENSSDUP00000007401 | CoA synthase. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.774 |
coasy | gch1 | ENSSDUP00000028969 | ENSSDUP00000024059 | CoA synthase. | GTP cyclohydrolase 1. | 0.523 |
eprs1 | coasy | ENSSDUP00000012304 | ENSSDUP00000028969 | Glutamyl-prolyl-tRNA synthetase. | CoA synthase. | 0.524 |
eprs1 | fpgs | ENSSDUP00000012304 | ENSSDUP00000025894 | Glutamyl-prolyl-tRNA synthetase. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.716 |
eprs1 | gart | ENSSDUP00000012304 | ENSSDUP00000007401 | Glutamyl-prolyl-tRNA synthetase. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.822 |
eprs1 | gch1 | ENSSDUP00000012304 | ENSSDUP00000024059 | Glutamyl-prolyl-tRNA synthetase. | GTP cyclohydrolase 1. | 0.581 |
eprs1 | itpa | ENSSDUP00000012304 | ENSSDUP00000022017 | Glutamyl-prolyl-tRNA synthetase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.486 |
fpgs | coasy | ENSSDUP00000025894 | ENSSDUP00000028969 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | CoA synthase. | 0.700 |
fpgs | eprs1 | ENSSDUP00000025894 | ENSSDUP00000012304 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Glutamyl-prolyl-tRNA synthetase. | 0.716 |
fpgs | gart | ENSSDUP00000025894 | ENSSDUP00000007401 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.727 |
fpgs | gch1 | ENSSDUP00000025894 | ENSSDUP00000024059 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase 1. | 0.652 |
fpgs | itpa | ENSSDUP00000025894 | ENSSDUP00000022017 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.573 |
fpgs | nudt15 | ENSSDUP00000025894 | ENSSDUP00000014240 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Nudix (nucleoside diphosphate linked moiety X)-type motif 15; Belongs to the Nudix hydrolase family. | 0.938 |
fpgs | pts | ENSSDUP00000025894 | ENSSDUP00000014235 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 6-pyruvoyl tetrahydrobiopterin synthase. | 0.643 |
gart | coasy | ENSSDUP00000007401 | ENSSDUP00000028969 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | CoA synthase. | 0.774 |
gart | eprs1 | ENSSDUP00000007401 | ENSSDUP00000012304 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Glutamyl-prolyl-tRNA synthetase. | 0.822 |
gart | fpgs | ENSSDUP00000007401 | ENSSDUP00000025894 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.727 |
gart | gch1 | ENSSDUP00000007401 | ENSSDUP00000024059 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | GTP cyclohydrolase 1. | 0.744 |