LOC111231790 protein (Seriola dumerili) - STRING interaction network

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Predicted Interactions

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Score

LOC111231790

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6. (382 aa)

Predicted Functional Partners:

ugcg

0.934

glb1

0.910

gba2

0.910

LOC111218581

0.910

gba

0.906

A3GALT2

0.869

LOC111236182

0.852

st3gal5

0.849

b3gnt5

0.832

LOC111231897

0.832

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A3GALT2	LOC111218581	ENSSDUP00000020433	ENSSDUP00000024474	Alpha 1,3-galactosyltransferase 2.	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	0.800
A3GALT2	LOC111231790	ENSSDUP00000020433	ENSSDUP00000025737	Alpha 1,3-galactosyltransferase 2.	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	0.869
A3GALT2	glb1	ENSSDUP00000020433	ENSSDUP00000003617	Alpha 1,3-galactosyltransferase 2.	Galactosidase, beta 1; Belongs to the glycosyl hydrolase 35 family.	0.800
LOC111218581	A3GALT2	ENSSDUP00000024474	ENSSDUP00000020433	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Alpha 1,3-galactosyltransferase 2.	0.800
LOC111218581	LOC111231790	ENSSDUP00000024474	ENSSDUP00000025737	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	0.910
LOC111218581	LOC111231897	ENSSDUP00000024474	ENSSDUP00000031429	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Hexosyltransferase.	0.800
LOC111218581	LOC111236182	ENSSDUP00000024474	ENSSDUP00000020298	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Hexosyltransferase.	0.800
LOC111218581	b3gnt5	ENSSDUP00000024474	ENSSDUP00000013861	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Hexosyltransferase.	0.800
LOC111218581	gba	ENSSDUP00000024474	ENSSDUP00000008845	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Glucosylceramidase.	0.932
LOC111218581	gba2	ENSSDUP00000024474	ENSSDUP00000010122	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.	0.911
LOC111218581	glb1	ENSSDUP00000024474	ENSSDUP00000003617	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	Galactosidase, beta 1; Belongs to the glycosyl hydrolase 35 family.	0.902
LOC111218581	st3gal5	ENSSDUP00000024474	ENSSDUP00000020192	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	ST3 beta-galactoside alpha-2,3-sialyltransferase 5; Belongs to the glycosyltransferase 29 family.	0.842
LOC111218581	ugcg	ENSSDUP00000024474	ENSSDUP00000003496	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	UDP-glucose ceramide glucosyltransferase.	0.920
LOC111231790	A3GALT2	ENSSDUP00000025737	ENSSDUP00000020433	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Alpha 1,3-galactosyltransferase 2.	0.869
LOC111231790	LOC111218581	ENSSDUP00000025737	ENSSDUP00000024474	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	0.910
LOC111231790	LOC111231897	ENSSDUP00000025737	ENSSDUP00000031429	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Hexosyltransferase.	0.832
LOC111231790	LOC111236182	ENSSDUP00000025737	ENSSDUP00000020298	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Hexosyltransferase.	0.852
LOC111231790	b3gnt5	ENSSDUP00000025737	ENSSDUP00000013861	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Hexosyltransferase.	0.832
LOC111231790	gba	ENSSDUP00000025737	ENSSDUP00000008845	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Glucosylceramidase.	0.906
LOC111231790	gba2	ENSSDUP00000025737	ENSSDUP00000010122	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6.	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.	0.910

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

29

PPI enrichment p-value:

5.4e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009112

Nucleobase metabolic process

9 of 65

2.81

10.31

4.13e-21

GO:0006206

Pyrimidine nucleobase metabolic process

8 of 38

2.99

10.01

8.33e-20

GO:0044205

De novo UMP biosynthetic process

5 of 11

3.33

6.63

7.82e-13

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

5 of 14

3.22

6.42

1.67e-12

GO:0046113

Nucleobase catabolic process

4 of 13

3.16

5.02

6.57e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016627

Oxidoreductase activity, acting on the CH-CH group of donors

4 of 176

2.02

1.97

0.00011

GO:0017113

Dihydropyrimidine dehydrogenase (NADP+) activity

2 of 2

3.67

1.97

0.00029

GO:0004590

orotidine-5-phosphate decarboxylase activity

2 of 2

3.67

1.97

0.00029

GO:0004588

Orotate phosphoribosyltransferase activity

2 of 2

3.67

1.97

0.00029

GO:0004152

Dihydroorotate dehydrogenase activity

2 of 2

3.67

1.97

0.00029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 18776

0.44

0.32

0.0139

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38192876

(2024) Chemotaxonomy, antibacterial and antioxidant activities of selected aromatic plants from Tabuk region-KSA.

2 of 3

3.49

1.63

0.0012

PMID:37243296

(2023) Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review.

2 of 2

3.67

1.63

0.0012

PMID:30949823

(2019) Untargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase.

2 of 2

3.67

1.63

0.0012

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21839

Mixed, incl. Dihydroorotate dehydrogenase, and Protein transport protein Got1

7 of 12

3.43

9.91

7.06e-19

CL:21816

Mixed, incl. Permease family, and Nucleobase catabolic process

8 of 45

2.92

9.45

7.06e-19

CL:21532

Pyrimidine metabolism, and Nucleoside monophosphate metabolic process

9 of 192

2.34

7.52

1.31e-17

CL:21853

Uracil catabolic process

3 of 5

3.45

3.57

3.58e-07

CL:21841

Pyrimidine biosynthesis, and Carbamoyl-phosphate synthase complex

3 of 6

3.37

3.49

4.83e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

han00240

Pyrimidine metabolism

8 of 74

2.7

9.07

6.65e-19

han00770

Pantothenate and CoA biosynthesis

3 of 42

2.52

2.83

4.64e-06

han00410

beta-Alanine metabolism

3 of 60

2.37

2.61

9.72e-06

han01100

Metabolic pathways

9 of 3064

1.14

1.5

3.27e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-500753

Pyrimidine biosynthesis

4 of 4

3.67

5.63

6.84e-11

MAP-8956320

Nucleotide biosynthesis

4 of 31

2.78

4.16

1.70e-08

MAP-15869

Metabolism of nucleotides

6 of 292

1.98

3.56

7.05e-09

MAP-73621

Pyrimidine catabolism

2 of 9

3.02

1.83

0.00049

MAP-373755

Semaphorin interactions

2 of 22

2.63

1.48

0.0020

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0140288

GBAF complex

2 of 2

3.67

1.91

0.00037

GOCC:0005737

Cytoplasm

10 of 13869

0.53

0.37

0.0128

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0288

FMN

2 of 23

2.61

1.36

0.0032

KW-0496

Mitochondrion

3 of 201

1.84

1.25

0.0032

KW-0285

Flavoprotein

3 of 206

1.83

1.24

0.0032

KW-0999

Mitochondrion inner membrane

2 of 64

2.16

1.14

0.0071

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01180

Dihydroorotate dehydrogenase

4 of 4

3.67

5.37

2.02e-10

PF01979

Amidohydrolase family

2 of 5

3.27

1.64

0.0011

PF00156

Phosphoribosyl transferase domain

2 of 22

2.63

1.11

0.0096

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005720

Dihydroorotate dehydrogenase domain

4 of 4

3.67

5.12

5.84e-10

IPR013785

Aldolase-type TIM barrel

6 of 157

2.25

4.23

1.56e-09

IPR023031

Orotate phosphoribosyltransferase

2 of 2

3.67

1.79

0.00061

IPR018089

Orotidine 5-phosphate decarboxylase, active site

2 of 2

3.67

1.79

0.00061

IPR014732

Orotidine 5-phosphate decarboxylase

2 of 2

3.67

1.79

0.00061

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00934

Orotidine 5-phosphate decarboxylase / HUMPS family

2 of 2

3.67

2.15

0.00014

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