node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc45 | cdc6 | ENSSDUP00000003823 | ENSSDUP00000001753 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.983 |
cdc45 | cdt1 | ENSSDUP00000003823 | ENSSDUP00000021969 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Chromatin licensing and DNA replication factor 1. | 0.953 |
cdc45 | mcm10 | ENSSDUP00000003823 | ENSSDUP00000020262 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Minichromosome maintenance 10 replication initiation factor. | 0.998 |
cdc45 | mcm2 | ENSSDUP00000003823 | ENSSDUP00000012879 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm3 | ENSSDUP00000003823 | ENSSDUP00000010875 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm4 | ENSSDUP00000003823 | ENSSDUP00000024940 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm5 | ENSSDUP00000003823 | ENSSDUP00000024162 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm7 | ENSSDUP00000003823 | ENSSDUP00000004513 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
cdc45 | mcm8 | ENSSDUP00000003823 | ENSSDUP00000029138 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | 0.977 |
cdc45 | orc2 | ENSSDUP00000003823 | ENSSDUP00000002322 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Origin recognition complex, subunit 2. | 0.985 |
cdc6 | cdc45 | ENSSDUP00000001753 | ENSSDUP00000003823 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.983 |
cdc6 | cdt1 | ENSSDUP00000001753 | ENSSDUP00000021969 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
cdc6 | mcm10 | ENSSDUP00000001753 | ENSSDUP00000020262 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Minichromosome maintenance 10 replication initiation factor. | 0.996 |
cdc6 | mcm2 | ENSSDUP00000001753 | ENSSDUP00000012879 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm3 | ENSSDUP00000001753 | ENSSDUP00000010875 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm4 | ENSSDUP00000001753 | ENSSDUP00000024940 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm5 | ENSSDUP00000001753 | ENSSDUP00000024162 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm7 | ENSSDUP00000001753 | ENSSDUP00000004513 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
cdc6 | mcm8 | ENSSDUP00000001753 | ENSSDUP00000029138 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | 0.995 |
cdc6 | orc2 | ENSSDUP00000001753 | ENSSDUP00000002322 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex, subunit 2. | 0.999 |