node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSSDUP00000023101 | FANCA | ENSSDUP00000023101 | ENSSDUP00000005235 | FA complementation group M. | FA complementation group A. | 0.997 |
ENSSDUP00000023101 | RPA1 | ENSSDUP00000023101 | ENSSDUP00000022462 | FA complementation group M. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.999 |
ENSSDUP00000023101 | atm | ENSSDUP00000023101 | ENSSDUP00000015925 | FA complementation group M. | Non-specific serine/threonine protein kinase. | 0.803 |
ENSSDUP00000023101 | atr | ENSSDUP00000023101 | ENSSDUP00000016484 | FA complementation group M. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.990 |
ENSSDUP00000023101 | atrip | ENSSDUP00000023101 | ENSSDUP00000029692 | FA complementation group M. | Uncharacterized protein. | 0.980 |
ENSSDUP00000023101 | brca1 | ENSSDUP00000023101 | ENSSDUP00000029899 | FA complementation group M. | Uncharacterized protein. | 0.724 |
ENSSDUP00000023101 | fancm | ENSSDUP00000023101 | ENSSDUP00000022982 | FA complementation group M. | Uncharacterized protein. | 0.987 |
ENSSDUP00000023101 | rpa1 | ENSSDUP00000023101 | ENSSDUP00000016384 | FA complementation group M. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.999 |
ENSSDUP00000023101 | slf1 | ENSSDUP00000023101 | ENSSDUP00000024520 | FA complementation group M. | SMC5-SMC6 complex localization factor 1. | 0.809 |
ENSSDUP00000023101 | topbp1 | ENSSDUP00000023101 | ENSSDUP00000014300 | FA complementation group M. | DNA topoisomerase II binding protein 1. | 0.742 |
FANCA | ENSSDUP00000023101 | ENSSDUP00000005235 | ENSSDUP00000023101 | FA complementation group A. | FA complementation group M. | 0.997 |
FANCA | RPA1 | ENSSDUP00000005235 | ENSSDUP00000022462 | FA complementation group A. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.945 |
FANCA | atm | ENSSDUP00000005235 | ENSSDUP00000015925 | FA complementation group A. | Non-specific serine/threonine protein kinase. | 0.471 |
FANCA | atr | ENSSDUP00000005235 | ENSSDUP00000016484 | FA complementation group A. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.680 |
FANCA | atrip | ENSSDUP00000005235 | ENSSDUP00000029692 | FA complementation group A. | Uncharacterized protein. | 0.978 |
FANCA | brca1 | ENSSDUP00000005235 | ENSSDUP00000029899 | FA complementation group A. | Uncharacterized protein. | 0.826 |
FANCA | fancm | ENSSDUP00000005235 | ENSSDUP00000022982 | FA complementation group A. | Uncharacterized protein. | 0.999 |
FANCA | rpa1 | ENSSDUP00000005235 | ENSSDUP00000016384 | FA complementation group A. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.945 |
RPA1 | ENSSDUP00000023101 | ENSSDUP00000022462 | ENSSDUP00000023101 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | FA complementation group M. | 0.999 |
RPA1 | FANCA | ENSSDUP00000022462 | ENSSDUP00000005235 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | FA complementation group A. | 0.945 |