rhobtb3 protein (Seriola dumerili) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

rhobtb3

Si:dkey-6b12.5. (619 aa)

Predicted Functional Partners:

LOC111217580

0.990

itsn2

0.990

itsn1

0.904

ENSSDUP00000004365

0.807

LOC111223136

0.725

myo9b

0.725

LOC111231068

0.725

LOC111229784

0.725

hgs

0.724

LOC111224075

0.704

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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... protein annotations:

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000004365	rhobtb3	ENSSDUP00000004365	ENSSDUP00000031223	Uncharacterized protein.	Si:dkey-6b12.5.	0.807
LOC111217580	hgs	ENSSDUP00000001735	ENSSDUP00000019903	Intersectin 2b.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.947
LOC111217580	itsn1	ENSSDUP00000001735	ENSSDUP00000019594	Intersectin 2b.	Intersectin 1 (SH3 domain protein).	0.950
LOC111217580	itsn2	ENSSDUP00000001735	ENSSDUP00000016866	Intersectin 2b.	Intersectin 2a.	0.958
LOC111217580	rhobtb3	ENSSDUP00000001735	ENSSDUP00000031223	Intersectin 2b.	Si:dkey-6b12.5.	0.990
LOC111223136	rhobtb3	ENSSDUP00000000515	ENSSDUP00000031223	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Si:dkey-6b12.5.	0.725
LOC111224075	rhobtb3	ENSSDUP00000000222	ENSSDUP00000031223	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Si:dkey-6b12.5.	0.704
LOC111229784	rhobtb3	ENSSDUP00000032764	ENSSDUP00000031223	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Si:dkey-6b12.5.	0.725
LOC111231068	rhobtb3	ENSSDUP00000016210	ENSSDUP00000031223	Myosin IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Si:dkey-6b12.5.	0.725
hgs	LOC111217580	ENSSDUP00000019903	ENSSDUP00000001735	Hepatocyte growth factor-regulated tyrosine kinase substrate.	Intersectin 2b.	0.947
hgs	itsn1	ENSSDUP00000019903	ENSSDUP00000019594	Hepatocyte growth factor-regulated tyrosine kinase substrate.	Intersectin 1 (SH3 domain protein).	0.677
hgs	itsn2	ENSSDUP00000019903	ENSSDUP00000016866	Hepatocyte growth factor-regulated tyrosine kinase substrate.	Intersectin 2a.	0.947
hgs	rhobtb3	ENSSDUP00000019903	ENSSDUP00000031223	Hepatocyte growth factor-regulated tyrosine kinase substrate.	Si:dkey-6b12.5.	0.724
itsn1	LOC111217580	ENSSDUP00000019594	ENSSDUP00000001735	Intersectin 1 (SH3 domain protein).	Intersectin 2b.	0.950
itsn1	hgs	ENSSDUP00000019594	ENSSDUP00000019903	Intersectin 1 (SH3 domain protein).	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.677
itsn1	itsn2	ENSSDUP00000019594	ENSSDUP00000016866	Intersectin 1 (SH3 domain protein).	Intersectin 2a.	0.950
itsn1	rhobtb3	ENSSDUP00000019594	ENSSDUP00000031223	Intersectin 1 (SH3 domain protein).	Si:dkey-6b12.5.	0.904
itsn2	LOC111217580	ENSSDUP00000016866	ENSSDUP00000001735	Intersectin 2a.	Intersectin 2b.	0.958
itsn2	hgs	ENSSDUP00000016866	ENSSDUP00000019903	Intersectin 2a.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.947
itsn2	itsn1	ENSSDUP00000016866	ENSSDUP00000019594	Intersectin 2a.	Intersectin 1 (SH3 domain protein).	0.950

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

4.11e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015813

L-glutamate transmembrane transport

8 of 34

2.68

8.21

4.55e-17

GO:0015804

Neutral amino acid transport

8 of 64

2.41

7.02

1.02e-15

GO:0098657

Import into cell

10 of 158

2.11

6.5

3.39e-17

GO:0140009

L-aspartate import across plasma membrane

5 of 8

3.11

6.13

5.03e-12

GO:0098712

L-glutamate import across plasma membrane

5 of 12

2.93

5.77

1.70e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015501

Glutamate:sodium symporter activity

7 of 14

3.01

8.7

3.97e-17

GO:0015370

Solute:sodium symporter activity

10 of 102

2.3

8.03

1.67e-19

GO:0005313

L-glutamate transmembrane transporter activity

7 of 25

2.76

7.79

6.81e-16

GO:0015175

Neutral amino acid transmembrane transporter activity

7 of 62

2.37

6.14

9.50e-14

GO:0008509

Anion transmembrane transporter activity

10 of 358

1.76

4.43

2.94e-15

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045202

Synapse

10 of 1052

1.29

2.02

6.44e-10

GO:0098793

Presynapse

5 of 385

1.43

1.51

8.55e-05

GO:0005887

Integral component of plasma membrane

9 of 1342

1.14

1.44

1.90e-07

GO:0032809

Neuronal cell body membrane

2 of 23

2.25

1.19

0.0060

GO:0045121

Membrane raft

3 of 138

1.65

1.13

0.0042

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:39553

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

10 of 20

3.01

12.83

1.55e-25

CL:39555

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

8 of 15

3.04

10.29

3.08e-20

CL:39557

Glutamate:sodium symporter activity, and Dopamine:sodium symporter activity

7 of 10

3.16

9.3

4.84e-18

CL:39559

D-amino acid transport, and Dopamine:sodium symporter activity

3 of 5

3.09

3.14

1.97e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 47

2.49

6.68

1.89e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-210500

Glutamate Neurotransmitter Release Cycle

7 of 52

2.44

6.21

1.54e-13

MAP-112310

Neurotransmitter release cycle

7 of 110

2.12

4.8

1.11e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

8 of 188

1.94

4.51

2.46e-12

MAP-425407

SLC-mediated transmembrane transport

10 of 424

1.69

3.85

1.10e-13

MAP-112315

Transmission across Chemical Synapses

8 of 444

1.57

2.79

1.04e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11939

0.28

0.25

0.0081

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

5 of 403

1.41

1.19

0.0012

GOCC:0032809

Neuronal cell body membrane

2 of 17

2.38

1.15

0.0077

GOCC:0005886

Plasma membrane

8 of 2464

0.82

0.67

0.0012

GOCC:0016020

Membrane

10 of 4744

0.64

0.51

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

10 of 60

2.53

10.07

1.58e-22

KW-1133

Transmembrane helix

11 of 6003

0.58

0.5

5.45e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00375

Sodium:dicarboxylate symporter family

7 of 17

2.93

8.11

3.96e-16

PF00209

Sodium:neurotransmitter symporter family

3 of 44

2.15

1.49

0.0014

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