| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RC1_0124 | lipA | RC1_0124 | RC1_0123 | Conserved hypothetical protein; Identified by match to protein family HMM PF00364 match to protein family HMM PF02779 match to protein family HMM PF02780. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.798 |
| RC1_0124 | pdhA | RC1_0124 | RC1_0119 | Conserved hypothetical protein; Identified by match to protein family HMM PF00364 match to protein family HMM PF02779 match to protein family HMM PF02780. | Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.460 |
| RC1_0124 | pdhB | RC1_0124 | RC1_0120 | Conserved hypothetical protein; Identified by match to protein family HMM PF00364 match to protein family HMM PF02779 match to protein family HMM PF02780. | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.498 |
| RC1_0124 | pdhC | RC1_0124 | RC1_0121 | Conserved hypothetical protein; Identified by match to protein family HMM PF00364 match to protein family HMM PF02779 match to protein family HMM PF02780. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.482 |
| RC1_0124 | pdhD | RC1_0124 | RC1_0122 | Conserved hypothetical protein; Identified by match to protein family HMM PF00364 match to protein family HMM PF02779 match to protein family HMM PF02780. | E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes identified by match to protein family HMM PF04977. | 0.512 |
| gcvH | lipA | RC1_3657 | RC1_0123 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.906 |
| gcvH | lipB | RC1_3657 | RC1_0407 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.889 |
| gcvH | merA | RC1_3657 | RC1_2279 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Mercuric reductase, putative; Also called Hg(II) reductase; identified by match to protein family HMM PF00070 match to protein family HMM PF01134 match to protein family HMM PF02852 match to protein family HMM PF07992 match to protein family HMM TIGR01350. | 0.835 |
| gcvH | pdhA | RC1_3657 | RC1_0119 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.823 |
| gcvH | pdhB | RC1_3657 | RC1_0120 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.927 |
| gcvH | pdhC | RC1_3657 | RC1_0121 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.845 |
| gcvH | pdhD | RC1_3657 | RC1_0122 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes identified by match to protein family HMM PF04977. | 0.986 |
| gcvH | sucB | RC1_3657 | RC1_2263 | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.845 |
| lipA | RC1_0124 | RC1_0123 | RC1_0124 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Conserved hypothetical protein; Identified by match to protein family HMM PF00364 match to protein family HMM PF02779 match to protein family HMM PF02780. | 0.798 |
| lipA | gcvH | RC1_0123 | RC1_3657 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.906 |
| lipA | lipB | RC1_0123 | RC1_0407 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.998 |
| lipA | merA | RC1_0123 | RC1_2279 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Mercuric reductase, putative; Also called Hg(II) reductase; identified by match to protein family HMM PF00070 match to protein family HMM PF01134 match to protein family HMM PF02852 match to protein family HMM PF07992 match to protein family HMM TIGR01350. | 0.576 |
| lipA | nrdA | RC1_0123 | RC1_3477 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.573 |
| lipA | pdhA | RC1_0123 | RC1_0119 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.718 |
| lipA | pdhB | RC1_0123 | RC1_0120 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.819 |
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