STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvBAcetolactate synthase large subunit, putative; Identified by match to protein family HMM PF01553; Belongs to the TPP enzyme family. (577 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01433 match to protein family HMM TIGR02414.
 
 0.998
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.994
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.977
ilvA
Threonine dehydratase; Identified by match to protein family HMM PF00830 match to protein family HMM TIGR00009.
 
 0.951
RC1_0779
Threonine dehydratase, putative; Synonym identified by match to protein family HMM PF00483.
 
 0.946
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.945
ilvD
Dihydroxy-acid dehydratase, putative; Identified by match to protein family HMM PF00581; Belongs to the IlvD/Edd family.
  
 0.941
RC1_1775
Thiamine pyrophosphate enzyme, putative; Identified by match to protein family HMM PF00072 match to protein family HMM PF01584 match to protein family HMM PF01627 match to protein family HMM PF02518 match to protein family HMM PF02895.
  
  
  0.927
ilvG
Acetolactate synthase isozyme II large subunit, putative; Identified by match to protein family HMM PF00378; Belongs to the TPP enzyme family.
  
  
 
0.926
ilvI
Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF01661.
  
  
 
0.924
Your Current Organism:
Rhodospirillum centenum
NCBI taxonomy Id: 414684
Other names: R. centenum SW, Rhodocista centenaria SW, Rhodospirillum centenum SW, Rhodospirillum centenum str. SW, Rhodospirillum centenum strain SW
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.