STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (930 aa)    
Predicted Functional Partners:
recQ
ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM TIGR01444.
 0.993
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.954
polA
DNA polymerase I, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.931
ssb
Single-strand DNA binding protein, putative; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
 
 0.914
dprA
DNA processing protein DprA, putative; Gene symbol synonym smf in E; coli.
   
 0.903
leuS
leucyl-tRNA synthetase LeuS; TIGR00396 With a good score above the trusted cutoff and characterized homologs; identified by match to protein family HMM PF06319; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.901
gltB
Glutamate synthase, large subunit.
  
  
 0.901
RC1_0450
Exonuclease, putative; Identified by match to protein family HMM PF00696 match to protein family HMM PF01472 match to protein family HMM TIGR01027.
  
 0.898
RC1_2036
UvrD; Identified by match to protein family HMM PF02417 match to protein family HMM TIGR00937.
 
 
 0.883
RC1_0099
Helicase, SNF2 family, putative.
  
 
 0.877
Your Current Organism:
Rhodospirillum centenum
NCBI taxonomy Id: 414684
Other names: R. centenum SW, Rhodocista centenaria SW, Rhodospirillum centenum SW, Rhodospirillum centenum str. SW, Rhodospirillum centenum strain SW
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.