STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa)    
Predicted Functional Partners:
thiD
[synonyms] HMP-phosphate kinase HMP-P kinase identified by match to protein family HMM PF00208 match to protein family HMM PF02812.
 
 0.999
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.978
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
  
 0.944
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.920
thiS
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF01381 match to protein family HMM TIGR02607.
  
  
 0.866
moeB
Molybdopterin biosynthesis protein MoeB; Identified by match to protein family HMM PF00515 match to protein family HMM PF07719 match to protein family HMM PF07721.
 
  
 0.835
RC1_1613
Tena; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.
 
  
 0.830
pstS
Phosphate ABC transporter, periplasmic phosphate-binding protein PstS, putative; Part of the pst operon; identified by match to protein family HMM PF01979 match to protein family HMM TIGR02022.
   
    0.690
fbaB
Fructose-bisphosphate aldolase, class I; Identified by match to protein family HMM PF00004 match to protein family HMM PF05491 match to protein family HMM PF05496 match to protein family HMM PF07728 match to protein family HMM TIGR00635.
       0.655
ribAB
Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
 
   
 0.540
Your Current Organism:
Rhodospirillum centenum
NCBI taxonomy Id: 414684
Other names: R. centenum SW, Rhodocista centenaria SW, Rhodospirillum centenum SW, Rhodospirillum centenum str. SW, Rhodospirillum centenum strain SW
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.