STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.999
dme
NAD-dependent malic enzyme; Identified by match to protein family HMM PF00441 match to protein family HMM PF02770 match to protein family HMM PF02771 match to protein family HMM PF08028.
  
 
 0.993
mdh-2
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.991
tme
NADP-dependent malic enzyme; Synonym gene name 'maeB' from E.coli identified by match to protein family HMM PF00392 match to protein family HMM PF07702 match to protein family HMM TIGR02018.
  
 
 0.988
sdhB
Succinate dehydrogenase iron-sulfur protein; Identified by match to protein family HMM PF00005; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.980
sdhC
Succinate dehydrogenase, cytochrome b556, putative; Synonym identified by match to protein family HMM PF02424 match to protein family HMM TIGR01409.
  
 
 0.979
aceB
Malate synthase A; Identified by match to protein family HMM PF00639; Belongs to the malate synthase family.
    
 0.977
gltA
Citrate synthase I; Both chromosomal and plasmid encoded identified by match to protein family HMM PF00015 match to protein family HMM PF00672; Belongs to the citrate synthase family.
   
 0.936
sdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit; Identified by match to protein family HMM PF05573.
  
 
 0.922
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.888
Your Current Organism:
Rhodospirillum centenum
NCBI taxonomy Id: 414684
Other names: R. centenum SW, Rhodocista centenaria SW, Rhodospirillum centenum SW, Rhodospirillum centenum str. SW, Rhodospirillum centenum strain SW
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.