Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
htpGMolecular chaperone,hSP90 family, putative; Molecular chaperone. Has ATPase activity. (631 aa)    
Predicted Functional Partners:
dnaK-2
Chaperone protein DnaK, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.990
dnaJ
Chaperone protein DnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...]
 
 0.984
groL
Chaperonin GroL, putative; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.979
dnaK
Heat shock protein DnaK, putative; NO HMMs but some uncharacterized homologs identified as HSP70; identified by match to protein family HMM PF02798.
  
 0.977
RC1_0582
DnaJ family, molecular chaperone, putative; PF01556 PF00226: DnaJ domain; Has many homologs from the same family; identified by match to protein family HMM PF00929.
 
 0.949
dnaJ-3
Chaperone protein DnaJ, putative; PF01556 Has uncharacterized homologs of the same identity; In a close position to other chaperonin genes in the same cluster; identified by match to protein family HMM PF00106.
  
 0.943
dnaJ-2
Chaperone protein DnaJ, putative; PF00226 Has uncharacterized homologs of the same identity; In a close position to other chaperonin genes in the same cluster.
  
 0.938
RC1_1700
Heat shock protein DnaJ, N-terminal, putative; PF00226 identified by match to protein family HMM PF00156.
  
 0.937
clpA
ATP-dependent Clp protease ATP-binding subunit ClpA; PF07724 PF02861: Clp amino terminal domain; PF07728: ATPase family associated With various cellular activities (AAA); SP:P05444: ClpA homolog protein; identified by match to protein family HMM PF01343; Belongs to the ClpA/ClpB family.
  
 
 0.926
clpB
ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.926
Your Current Organism:
Rhodospirillum centenum
NCBI taxonomy Id: 414684
Other names: R. centenum SW, Rhodocista centenaria SW, Rhodospirillum centenum SW, Rhodospirillum centenum str. SW, Rhodospirillum centenum strain SW
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