STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPAGlycine cleavage system P-protein subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (449 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system T protein; Identified by match to protein family HMM PF07690.
 
 0.999
gcvH
Glycine cleavage systemh protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvPB
[synonyms] glycine dehydrogenase [decarboxylating] subunit 2 Glycine decarboxylase subunit 2 identified by match to protein family HMM PF01523.
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.971
lpdA
Dihydrolipoamide dehydrogenase.
 
 
 0.938
pdhD
E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes identified by match to protein family HMM PF04977.
 
 
 0.935
ltaE
Low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
    
 0.923
hemA
[synonyms] 5-aminolevulinic acid synt Hase Delta-aminolevulinate synt Hase Delta-ALA synthetase identified by match to protein family HMM PF00462 match to protein family HMM TIGR00365.
  
 
 0.914
hemA-2
5-aminolevulinic acid synthase; Identified by match to protein family HMM PF00561 match to protein family HMM TIGR03056.
  
 
 0.914
gltB
Glutamate synthase, large subunit.
   
 
 0.880
Your Current Organism:
Rhodospirillum centenum
NCBI taxonomy Id: 414684
Other names: R. centenum SW, Rhodocista centenaria SW, Rhodospirillum centenum SW, Rhodospirillum centenum str. SW, Rhodospirillum centenum strain SW
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