| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SFK35407.1 | SFL50598.1 | SAMN04488125_101367 | SAMN04488125_116124 | Porphobilinogen synthase; Belongs to the ALAD family. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.662 |
| SFK35407.1 | SFL84668.1 | SAMN04488125_101367 | SAMN04488125_1276 | Porphobilinogen synthase; Belongs to the ALAD family. | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.427 |
| SFK35407.1 | hemE | SAMN04488125_101367 | SAMN04488125_13321 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.915 |
| SFK35407.1 | hemH | SAMN04488125_101367 | SAMN04488125_10430 | Porphobilinogen synthase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.633 |
| SFK52179.1 | SFL50598.1 | SAMN04488125_102266 | SAMN04488125_116124 | L-alanine-DL-glutamate epimerase. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.664 |
| SFK52179.1 | SFL84668.1 | SAMN04488125_102266 | SAMN04488125_1276 | L-alanine-DL-glutamate epimerase. | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.664 |
| SFK92793.1 | SFL50598.1 | SAMN04488125_10628 | SAMN04488125_116124 | HemY protein. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.764 |
| SFK92793.1 | hemH | SAMN04488125_10628 | SAMN04488125_10430 | HemY protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.810 |
| SFL50598.1 | SFK35407.1 | SAMN04488125_116124 | SAMN04488125_101367 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.662 |
| SFL50598.1 | SFK52179.1 | SAMN04488125_116124 | SAMN04488125_102266 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | L-alanine-DL-glutamate epimerase. | 0.664 |
| SFL50598.1 | SFK92793.1 | SAMN04488125_116124 | SAMN04488125_10628 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | HemY protein. | 0.764 |
| SFL50598.1 | SFL50615.1 | SAMN04488125_116124 | SAMN04488125_116125 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Exodeoxyribonuclease-5. | 0.838 |
| SFL50598.1 | SFL84668.1 | SAMN04488125_116124 | SAMN04488125_1276 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.760 |
| SFL50598.1 | SFL90253.1 | SAMN04488125_116124 | SAMN04488125_12948 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Uncharacterized membrane protein. | 0.832 |
| SFL50598.1 | SFL96358.1 | SAMN04488125_116124 | SAMN04488125_13320 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative membrane protein. | 0.883 |
| SFL50598.1 | hemE | SAMN04488125_116124 | SAMN04488125_13321 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.977 |
| SFL50598.1 | hemH | SAMN04488125_116124 | SAMN04488125_10430 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.715 |
| SFL50598.1 | trmL | SAMN04488125_116124 | SAMN04488125_116120 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | tRNA (cytidine/uridine-2'-O-)-methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.853 |
| SFL50615.1 | SFL50598.1 | SAMN04488125_116125 | SAMN04488125_116124 | Exodeoxyribonuclease-5. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.838 |
| SFL50615.1 | trmL | SAMN04488125_116125 | SAMN04488125_116120 | Exodeoxyribonuclease-5. | tRNA (cytidine/uridine-2'-O-)-methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.471 |