node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFL08466.1 | SFL40191.1 | SAMN04488125_108137 | SAMN04488125_11466 | Glutamate synthase (NADPH/NADH) large chain. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.443 |
SFL08466.1 | SFL65522.1 | SAMN04488125_108137 | SAMN04488125_12023 | Glutamate synthase (NADPH/NADH) large chain. | Aminomethyltransferase; Belongs to the GcvT family. | 0.912 |
SFL08466.1 | SFL75399.1 | SAMN04488125_108137 | SAMN04488125_12360 | Glutamate synthase (NADPH/NADH) large chain. | N-methylglutamate dehydrogenase subunit A precursor. | 0.911 |
SFL08466.1 | SFL75429.1 | SAMN04488125_108137 | SAMN04488125_12361 | Glutamate synthase (NADPH/NADH) large chain. | N-methylglutamate dehydrogenase subunit B. | 0.891 |
SFL08466.1 | gcvH | SAMN04488125_108137 | SAMN04488125_13526 | Glutamate synthase (NADPH/NADH) large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.909 |
SFL08466.1 | gcvP | SAMN04488125_108137 | SAMN04488125_13525 | Glutamate synthase (NADPH/NADH) large chain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.930 |
SFL08466.1 | glyA | SAMN04488125_108137 | SAMN04488125_109158 | Glutamate synthase (NADPH/NADH) large chain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.917 |
SFL40191.1 | SFL08466.1 | SAMN04488125_11466 | SAMN04488125_108137 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.443 |
SFL40191.1 | SFL65522.1 | SAMN04488125_11466 | SAMN04488125_12023 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; Belongs to the GcvT family. | 0.934 |
SFL40191.1 | SFL75399.1 | SAMN04488125_11466 | SAMN04488125_12360 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | N-methylglutamate dehydrogenase subunit A precursor. | 0.816 |
SFL40191.1 | gcvH | SAMN04488125_11466 | SAMN04488125_13526 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.868 |
SFL40191.1 | gcvP | SAMN04488125_11466 | SAMN04488125_13525 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.887 |
SFL40191.1 | glyA | SAMN04488125_11466 | SAMN04488125_109158 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |
SFL65296.1 | SFL65359.1 | SAMN04488125_12016 | SAMN04488125_12018 | Protein of unknown function. | Hypothetical protein. | 0.959 |
SFL65296.1 | SFL65490.1 | SAMN04488125_12016 | SAMN04488125_12022 | Protein of unknown function. | Trimethylamine monooxygenase. | 0.789 |
SFL65296.1 | SFL65522.1 | SAMN04488125_12016 | SAMN04488125_12023 | Protein of unknown function. | Aminomethyltransferase; Belongs to the GcvT family. | 0.911 |
SFL65359.1 | SFL65296.1 | SAMN04488125_12018 | SAMN04488125_12016 | Hypothetical protein. | Protein of unknown function. | 0.959 |
SFL65359.1 | SFL65490.1 | SAMN04488125_12018 | SAMN04488125_12022 | Hypothetical protein. | Trimethylamine monooxygenase. | 0.786 |
SFL65359.1 | SFL65522.1 | SAMN04488125_12018 | SAMN04488125_12023 | Hypothetical protein. | Aminomethyltransferase; Belongs to the GcvT family. | 0.947 |
SFL65490.1 | SFL65296.1 | SAMN04488125_12022 | SAMN04488125_12016 | Trimethylamine monooxygenase. | Protein of unknown function. | 0.789 |