| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABX22672.1 | ABX24315.1 | SARI_02824 | SARI_04542 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.903 |
| ABX22672.1 | gmk | SARI_02824 | SARI_03899 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. | 0.940 |
| ABX22672.1 | gpt | SARI_02824 | SARI_02695 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.934 |
| ABX22672.1 | guaA | SARI_02824 | SARI_00366 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Catalyzes the synthesis of GMP from XMP. | 0.974 |
| ABX22672.1 | guaB | SARI_02824 | SARI_00365 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.950 |
| ABX22672.1 | guaC | SARI_02824 | SARI_02854 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.929 |
| ABX22672.1 | purH | SARI_02824 | SARI_03481 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; KEGG: stm:STM4176 9.3e-271 purH; bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score:8.96. | 0.947 |
| ABX22672.1 | purL | SARI_02824 | SARI_00310 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.409 |
| ABX22672.1 | surE | SARI_02824 | SARI_00029 | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Hypothetical protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.927 |
| ABX24315.1 | ABX22672.1 | SARI_04542 | SARI_02824 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.903 |
| ABX24315.1 | gpt | SARI_04542 | SARI_02695 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.920 |
| ABX24315.1 | guaA | SARI_04542 | SARI_00366 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Catalyzes the synthesis of GMP from XMP. | 0.965 |
| ABX24315.1 | guaB | SARI_04542 | SARI_00365 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.936 |
| ABX24315.1 | guaC | SARI_04542 | SARI_02854 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.915 |
| ABX24315.1 | purH | SARI_04542 | SARI_03481 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; KEGG: stm:STM4176 9.3e-271 purH; bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score:8.96. | 0.916 |
| ABX24315.1 | surE | SARI_04542 | SARI_00029 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.901 |
| gmk | ABX22672.1 | SARI_03899 | SARI_02824 | Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. | Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.940 |
| gmk | gpt | SARI_03899 | SARI_02695 | Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. | Hypothetical protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.944 |
| gmk | guaA | SARI_03899 | SARI_00366 | Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. | Hypothetical protein; Catalyzes the synthesis of GMP from XMP. | 0.974 |
| gmk | guaB | SARI_03899 | SARI_00365 | Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. | Hypothetical protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.522 |
