STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aptHypothetical protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)    
Predicted Functional Partners:
guaA
Hypothetical protein; Catalyzes the synthesis of GMP from XMP.
  
 0.988
purH
Hypothetical protein; KEGG: stm:STM4176 9.3e-271 purH; bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score:8.96.
 
 0.955
gpt
Hypothetical protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.949
gmk
Hypothetical protein; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.949
ABX21644.1
Hypothetical protein; KEGG: stm:STM1232 1.0e-239 purB; adenylosuccinate lyase K01756; COG: COG0015 Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.947
ABX22672.1
Hypothetical protein; KEGG: sec:SC0170 2.4e-91 hpt; hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 0.938
adk
Hypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.930
ABX20385.1
Hypothetical protein; KEGG: noc:Noc_2237 3.9e-27 glutamine amidotransferase class-I K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score:8.96.
  
 
 0.927
guaC
Hypothetical protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 
 0.927
ABX22304.1
Hypothetical protein; KEGG: stm:STM0491 6.8e-236 gsk; inosine-guanosine kinase K00892; COG: COG0524 Sugar kinases, ribokinase family.
   
 0.923
Your Current Organism:
Salmonella enterica arizonae
NCBI taxonomy Id: 41514
Other names: S. enterica subsp. arizonae serovar 62:z4,z23:-, Salmonella enterica IIIa 62:z4,z23:-, Salmonella enterica serovar IIIa 62:z4,z23:-, Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.