Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
ABX23301.1Hypothetical protein; KEGG: spt:SPA4022 5.7e-232 aceA; isocitrate lyase K01637; COG: COG2224 Isocitrate lyase; Psort location: Cytoplasmic, score:9.97. (439 aa)    
Predicted Functional Partners:
ABX23302.1
Hypothetical protein; KEGG: stm:STM4183 4.6e-285 aceB; malate synthase A K01638; COG: COG2225 Malate synthase; Psort location: Cytoplasmic, score:9.97.
 
 0.999
aceK
Hypothetical protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
  
 0.990
ABX20488.1
Hypothetical protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
   
 
 0.949
ABX21152.1
Hypothetical protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
   
 
 0.932
ABX22683.1
Hypothetical protein; KEGG: sty:STY0181 0. acnB; aconitate hydratase 2 (citrate hydro-lyase 2) K01682; COG: COG1049 Aconitase B; Psort location: Cytoplasmic, score:8.96; Belongs to the aconitase/IPM isomerase family.
   
 
 0.928
sucC
Hypothetical protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.925
prpB
Hypothetical protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
  
0.924
ABX20354.1
Hypothetical protein; KEGG: eci:UTI89_C2782 3.1e-153 eutD, ypfA, eutI; ethanolamine utilization protein EutD acetyl/butyryl phosphate transferase K04020; COG: COG0280 Phosphotransacetylase.
   
 
 0.921
ghrA
Hypothetical protein; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
   
 
 0.921
sucD
Hypothetical protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 
 0.920
Your Current Organism:
Salmonella enterica arizonae
NCBI taxonomy Id: 41514
Other names: S. enterica subsp. arizonae serovar 62:z4,z23:-, Salmonella enterica IIIa 62:z4,z23:-, Salmonella enterica serovar IIIa 62:z4,z23:-, Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
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