STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEHypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)    
Predicted Functional Partners:
ABX20676.1
Hypothetical protein; KEGG: stm:STM2146 2.8e-136 thiD; bifunctional enzyme: hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase); hydroxy-methylpyrimidine kinase (HMP kinase) K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 0.999
thiG
Hypothetical protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.999
thiM
Hypothetical protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
 
 0.997
ABX23324.1
Hypothetical protein; KEGG: mac:MA0154 1.0e-11 bioB; biotin synthase K01012; COG: COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
 
  
 0.995
ABX23321.1
Hypothetical protein; KEGG: eci:UTI89_C3827 2.2e-111 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
 
  
 0.994
thiL
Hypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.988
thiC
Hypothetical protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
 0.984
ABX23322.1
COG: COG2104 Sulfur transfer protein involved in thiamine biosynthesis.
  
  
 0.967
ABX21669.1
Hypothetical protein; KEGG: stt:t1712 2.2e-95 thiamine kinase K07251; COG: COG0510 Predicted choline kinase involved in LPS biosynthesis.
     
 0.916
rsgA
Hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.910
Your Current Organism:
Salmonella enterica arizonae
NCBI taxonomy Id: 41514
Other names: S. enterica subsp. arizonae serovar 62:z4,z23:-, Salmonella enterica IIIa 62:z4,z23:-, Salmonella enterica serovar IIIa 62:z4,z23:-, Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.