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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiGHypothetical protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)    
Predicted Functional Partners:
thiE
Hypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.999
ABX23324.1
Hypothetical protein; KEGG: mac:MA0154 1.0e-11 bioB; biotin synthase K01012; COG: COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
 
 0.999
ABX23322.1
COG: COG2104 Sulfur transfer protein involved in thiamine biosynthesis.
  
 
 0.997
ABX23321.1
Hypothetical protein; KEGG: eci:UTI89_C3827 2.2e-111 thiF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
 
  
 0.995
thiC
Hypothetical protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.993
ABX20676.1
Hypothetical protein; KEGG: stm:STM2146 2.8e-136 thiD; bifunctional enzyme: hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase); hydroxy-methylpyrimidine kinase (HMP kinase) K00877:K00941; COG: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
  
 0.960
thiI
Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.951
dxs
Hypothetical protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.933
ABX21955.1
Hypothetical protein; KEGG: eci:UTI89_C0829 1.4e-116 moeB; molybdopterin biosynthesis protein MoeB K03751; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; Psort location: Cytoplasmic, score:8.96.
 
  
 0.820
ABX23185.1
Hypothetical protein; KEGG: ech:ECH_1107 3.6e-14 thiF; adenylyltransferase ThiF; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
 
  
 0.791
Your Current Organism:
Salmonella enterica arizonae
NCBI taxonomy Id: 41514
Other names: S. enterica subsp. arizonae serovar 62:z4,z23:-, Salmonella enterica IIIa 62:z4,z23:-, Salmonella enterica serovar IIIa 62:z4,z23:-, Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
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