STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnEHypothetical protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB [...] (947 aa)    
Predicted Functional Partners:
glnD
Hypothetical protein; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.828
ABX23463.1
Hypothetical protein; KEGG: sdy:SDY_3873 9.7e-253 glnA; glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: Cytoplasmic, score:9.97.
 
  
 0.762
ABX24077.1
Hypothetical protein; KEGG: stt:t3247 0. gltB; glutamate synthase [NADPH] large chain precursor K00265; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score:8.96.
     
 0.675
hldE
Hypothetical protein; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.
       0.673
ABX24204.1
Hypothetical protein; KEGG: aha:AHA_3770 3.3e-37 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein.
       0.572
ABX24203.1
Hypothetical protein; KEGG: bsu:BG13806 0.0074 yrvJ; N-acetylmuramoyl-L-alanine amidase, peptidoglycan hydrolase, LytC amidase family K01448; COG: COG3103 SH3 domain protein.
 
     0.559
ABX24079.1
Hypothetical protein; KEGG: sec:SC3266 0. arcB; aerobic respiration control sensor protein K07648; COG: COG0784 FOG: CheY-like receiver; Psort location: CytoplasmicMembrane, score:9.97.
     
 0.460
ABX20203.1
Hypothetical protein; KEGG: sty:STY2856 6.7e-190 tyrA; prephenate dehydrogenase / chorismate mutase K04092:K04517; COG: COG1605 Chorismate mutase.
  
   
 0.444
ABX20328.1
Hypothetical protein; KEGG: ecj:JW2465 8.2e-82 bcp; thiol peroxidase, thioredoxin-dependent K03564; COG: COG1225 Peroxiredoxin; Psort location: Cytoplasmic, score:8.96.
      0.439
ABX20972.1
COG: COG3141 Uncharacterized protein conserved in bacteria.
  
     0.429
Your Current Organism:
Salmonella enterica arizonae
NCBI taxonomy Id: 41514
Other names: S. enterica subsp. arizonae serovar 62:z4,z23:-, Salmonella enterica IIIa 62:z4,z23:-, Salmonella enterica serovar IIIa 62:z4,z23:-, Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.