node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hbut_0060 | Hbut_1070 | Hbut_0060 | Hbut_1070 | Cytidylyl transferase, TagD; Includes extra conserved archaeal domain. | Universally conserved protein. | 0.406 |
Hbut_0060 | dphB | Hbut_0060 | Hbut_0128 | Cytidylyl transferase, TagD; Includes extra conserved archaeal domain. | Predicted Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.684 |
Hbut_0072 | Hbut_1405 | Hbut_0072 | Hbut_1405 | RIO-like serine/threonine kinase. | Universally conserved protein. | 0.977 |
Hbut_0072 | Hbut_1558 | Hbut_0072 | Hbut_1558 | RIO-like serine/threonine kinase. | Conserved archaeal protein. | 0.615 |
Hbut_0072 | Hbut_1652 | Hbut_0072 | Hbut_1652 | RIO-like serine/threonine kinase. | Conserved archaeal protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.503 |
Hbut_0072 | dphB | Hbut_0072 | Hbut_0128 | RIO-like serine/threonine kinase. | Predicted Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.593 |
Hbut_0072 | rtcA | Hbut_0072 | Hbut_1561 | RIO-like serine/threonine kinase. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.763 |
Hbut_0129 | dphB | Hbut_0129 | Hbut_0128 | Hexulose-6-phosphate synthase. | Predicted Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.568 |
Hbut_1070 | Hbut_0060 | Hbut_1070 | Hbut_0060 | Universally conserved protein. | Cytidylyl transferase, TagD; Includes extra conserved archaeal domain. | 0.406 |
Hbut_1070 | Hbut_1652 | Hbut_1070 | Hbut_1652 | Universally conserved protein. | Conserved archaeal protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.602 |
Hbut_1070 | dphB | Hbut_1070 | Hbut_0128 | Universally conserved protein. | Predicted Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.699 |
Hbut_1070 | fusA | Hbut_1070 | Hbut_0840 | Universally conserved protein. | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.999 |
Hbut_1405 | Hbut_0072 | Hbut_1405 | Hbut_0072 | Universally conserved protein. | RIO-like serine/threonine kinase. | 0.977 |
Hbut_1405 | Hbut_1558 | Hbut_1405 | Hbut_1558 | Universally conserved protein. | Conserved archaeal protein. | 0.938 |
Hbut_1405 | Hbut_1652 | Hbut_1405 | Hbut_1652 | Universally conserved protein. | Conserved archaeal protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.440 |
Hbut_1405 | dphB | Hbut_1405 | Hbut_0128 | Universally conserved protein. | Predicted Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.512 |
Hbut_1405 | rtcA | Hbut_1405 | Hbut_1561 | Universally conserved protein. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.956 |
Hbut_1558 | Hbut_0072 | Hbut_1558 | Hbut_0072 | Conserved archaeal protein. | RIO-like serine/threonine kinase. | 0.615 |
Hbut_1558 | Hbut_1405 | Hbut_1558 | Hbut_1405 | Conserved archaeal protein. | Universally conserved protein. | 0.938 |
Hbut_1558 | dphB | Hbut_1558 | Hbut_0128 | Conserved archaeal protein. | Predicted Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.636 |