| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Hbut_0471 | Hbut_1135 | Hbut_0471 | Hbut_1135 | Putative RNA modification enzyme. | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.414 |
| Hbut_0471 | Hbut_1137 | Hbut_0471 | Hbut_1137 | Putative RNA modification enzyme. | Conserved archaeal protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.679 |
| Hbut_0471 | Hbut_1139 | Hbut_0471 | Hbut_1139 | Putative RNA modification enzyme. | Conserved archaeal protein. | 0.832 |
| Hbut_0471 | hflX | Hbut_0471 | Hbut_1138 | Putative RNA modification enzyme. | GTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.624 |
| Hbut_0471 | pan | Hbut_0471 | Hbut_1140 | Putative RNA modification enzyme. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.709 |
| Hbut_0471 | tfe | Hbut_0471 | Hbut_1136 | Putative RNA modification enzyme. | Predicted transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and dest [...] | 0.654 |
| Hbut_0471 | tiaS | Hbut_0471 | Hbut_0008 | Putative RNA modification enzyme. | Nucleic acid binding protein with Zn ribbon domain - conserved archaeal protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.467 |
| Hbut_1082 | Hbut_1137 | Hbut_1082 | Hbut_1137 | Conserved archaeal protein. | Conserved archaeal protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.558 |
| Hbut_1082 | Hbut_1139 | Hbut_1082 | Hbut_1139 | Conserved archaeal protein. | Conserved archaeal protein. | 0.420 |
| Hbut_1134 | Hbut_1135 | Hbut_1134 | Hbut_1135 | Conserved crenarchaeal protein. | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.728 |
| Hbut_1134 | Hbut_1137 | Hbut_1134 | Hbut_1137 | Conserved crenarchaeal protein. | Conserved archaeal protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.624 |
| Hbut_1134 | Hbut_1139 | Hbut_1134 | Hbut_1139 | Conserved crenarchaeal protein. | Conserved archaeal protein. | 0.624 |
| Hbut_1134 | hflX | Hbut_1134 | Hbut_1138 | Conserved crenarchaeal protein. | GTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.624 |
| Hbut_1134 | pan | Hbut_1134 | Hbut_1140 | Conserved crenarchaeal protein. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.503 |
| Hbut_1134 | tfe | Hbut_1134 | Hbut_1136 | Conserved crenarchaeal protein. | Predicted transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and dest [...] | 0.728 |
| Hbut_1135 | Hbut_0471 | Hbut_1135 | Hbut_0471 | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Putative RNA modification enzyme. | 0.414 |
| Hbut_1135 | Hbut_1134 | Hbut_1135 | Hbut_1134 | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Conserved crenarchaeal protein. | 0.728 |
| Hbut_1135 | Hbut_1137 | Hbut_1135 | Hbut_1137 | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Conserved archaeal protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.912 |
| Hbut_1135 | Hbut_1139 | Hbut_1135 | Hbut_1139 | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Conserved archaeal protein. | 0.875 |
| Hbut_1135 | hflX | Hbut_1135 | Hbut_1138 | Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | GTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.912 |
