node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hbut_0827 | Hbut_0896 | Hbut_0827 | Hbut_0896 | Conserved archaeal protein. | DNA polymerase III. | 0.730 |
Hbut_0827 | Hbut_1274 | Hbut_0827 | Hbut_1274 | Conserved archaeal protein. | DNA polymerase I. | 0.776 |
Hbut_0827 | fen | Hbut_0827 | Hbut_1366 | Conserved archaeal protein. | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | 0.758 |
Hbut_0827 | lig | Hbut_0827 | Hbut_0421 | Conserved archaeal protein. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can use ATP, ADP and GTP, but not CTP, TTP or NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.743 |
Hbut_0827 | pcn | Hbut_0827 | Hbut_0018 | Conserved archaeal protein. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.866 |
Hbut_0827 | pcn-2 | Hbut_0827 | Hbut_1286 | Conserved archaeal protein. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.866 |
Hbut_0827 | pcn-3 | Hbut_0827 | Hbut_1645 | Conserved archaeal protein. | DNA polymerase sliding clamp B2; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.863 |
Hbut_0827 | priL | Hbut_0827 | Hbut_1102 | Conserved archaeal protein. | Conserved archaeal protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.827 |
Hbut_0827 | priS | Hbut_0827 | Hbut_1644 | Conserved archaeal protein. | Probable DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer sy [...] | 0.803 |
Hbut_0827 | rfcL | Hbut_0827 | Hbut_0906 | Conserved archaeal protein. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.866 |
Hbut_0896 | Hbut_0827 | Hbut_0896 | Hbut_0827 | DNA polymerase III. | Conserved archaeal protein. | 0.730 |
Hbut_0896 | Hbut_1274 | Hbut_0896 | Hbut_1274 | DNA polymerase III. | DNA polymerase I. | 0.926 |
Hbut_0896 | fen | Hbut_0896 | Hbut_1366 | DNA polymerase III. | Endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] | 0.885 |
Hbut_0896 | lig | Hbut_0896 | Hbut_0421 | DNA polymerase III. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can use ATP, ADP and GTP, but not CTP, TTP or NAD(+); Belongs to the ATP-dependent DNA ligase family. | 0.768 |
Hbut_0896 | pcn | Hbut_0896 | Hbut_0018 | DNA polymerase III. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.846 |
Hbut_0896 | pcn-2 | Hbut_0896 | Hbut_1286 | DNA polymerase III. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.846 |
Hbut_0896 | pcn-3 | Hbut_0896 | Hbut_1645 | DNA polymerase III. | DNA polymerase sliding clamp B2; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.846 |
Hbut_0896 | priL | Hbut_0896 | Hbut_1102 | DNA polymerase III. | Conserved archaeal protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.958 |
Hbut_0896 | priS | Hbut_0896 | Hbut_1644 | DNA polymerase III. | Probable DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer sy [...] | 0.945 |
Hbut_0896 | rfcL | Hbut_0896 | Hbut_0906 | DNA polymerase III. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.792 |