STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCZ61259.1Transcriptional regulator, IclR family. (252 aa)    
Predicted Functional Partners:
SCZ49123.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase.
    
 0.863
SCZ57433.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase.
    
  0.853
SCZ61273.1
Uncharacterized conserved protein YgbK, DUF1537 family.
 
     0.615
SCZ61264.1
Phosphoketolase.
 
     0.612
SCZ65051.1
TRAP transporter, DctM subunit.
 
  
  0.585
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
     
 0.559
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 
 0.547
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
  0.537
SCZ58916.1
Pyruvate carboxylase subunit B.
 
  
  0.527
SCZ62120.1
Sugar phosphate permease.
 
  
 0.513
Your Current Organism:
Thiohalomonas denitrificans
NCBI taxonomy Id: 415747
Other names: DSM 15841, T. denitrificans, Thiohalomonas denitrificans Sorokin et al. 2007, UNIQEM U222, halophilic bacterium HLD 1, halophilic bacterium HLD 16, strain HLD 2
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