node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHO71874.1 | SHO72816.1 | SAMN05443547_0190 | SAMN05443547_1156 | Cystathionine beta-synthase. | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 0.948 |
SHO71874.1 | glyA | SAMN05443547_0190 | SAMN05443547_1311 | Cystathionine beta-synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
SHO71874.1 | trpA | SAMN05443547_0190 | SAMN05443547_2024 | Cystathionine beta-synthase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.920 |
SHO71874.1 | trpB | SAMN05443547_0190 | SAMN05443547_2025 | Cystathionine beta-synthase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.905 |
SHO71874.1 | trpC | SAMN05443547_0190 | SAMN05443547_2027 | Cystathionine beta-synthase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.603 |
SHO71874.1 | trpF | SAMN05443547_0190 | SAMN05443547_2026 | Cystathionine beta-synthase. | Phosphoribosylanthranilate isomerase; Manually curated; Belongs to the TrpF family. | 0.943 |
SHO72816.1 | SHO71874.1 | SAMN05443547_1156 | SAMN05443547_0190 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine beta-synthase. | 0.948 |
SHO72816.1 | SHO73596.1 | SAMN05443547_1156 | SAMN05443547_1958 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Para-aminobenzoate synthetase component 1. | 0.424 |
SHO72816.1 | SHO73664.1 | SAMN05443547_1156 | SAMN05443547_2030 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Anthranilate synthase component 1. | 0.424 |
SHO72816.1 | glyA | SAMN05443547_1156 | SAMN05443547_1311 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
SHO72816.1 | trpA | SAMN05443547_1156 | SAMN05443547_2024 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.929 |
SHO72816.1 | trpB | SAMN05443547_1156 | SAMN05443547_2025 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.870 |
SHO72816.1 | trpC | SAMN05443547_1156 | SAMN05443547_2027 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.579 |
SHO72816.1 | trpD | SAMN05443547_1156 | SAMN05443547_2028 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.678 |
SHO72816.1 | trpF | SAMN05443547_1156 | SAMN05443547_2026 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Phosphoribosylanthranilate isomerase; Manually curated; Belongs to the TrpF family. | 0.971 |
SHO73596.1 | SHO72816.1 | SAMN05443547_1958 | SAMN05443547_1156 | Para-aminobenzoate synthetase component 1. | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 0.424 |
SHO73596.1 | SHO73663.1 | SAMN05443547_1958 | SAMN05443547_2029 | Para-aminobenzoate synthetase component 1. | Anthranilate synthase component 2. | 0.999 |
SHO73596.1 | SHO73664.1 | SAMN05443547_1958 | SAMN05443547_2030 | Para-aminobenzoate synthetase component 1. | Anthranilate synthase component 1. | 0.928 |
SHO73596.1 | trpA | SAMN05443547_1958 | SAMN05443547_2024 | Para-aminobenzoate synthetase component 1. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.904 |
SHO73596.1 | trpB | SAMN05443547_1958 | SAMN05443547_2025 | Para-aminobenzoate synthetase component 1. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.872 |