node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHO72824.1 | hisB | SAMN05443547_1164 | SAMN05443547_2514 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.704 |
SHO72824.1 | hisC | SAMN05443547_1164 | SAMN05443547_2515 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.847 |
SHO72824.1 | trpF | SAMN05443547_1164 | SAMN05443547_2026 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. | Phosphoribosylanthranilate isomerase; Manually curated; Belongs to the TrpF family. | 0.766 |
SHO73908.1 | hisA | SAMN05443547_2284 | SAMN05443547_2512 | Phosphoserine phosphatase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.715 |
SHO73908.1 | hisB | SAMN05443547_2284 | SAMN05443547_2514 | Phosphoserine phosphatase. | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.883 |
SHO73908.1 | hisC | SAMN05443547_2284 | SAMN05443547_2515 | Phosphoserine phosphatase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.627 |
SHO73908.1 | hisD | SAMN05443547_2284 | SAMN05443547_2516 | Phosphoserine phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.684 |
SHO73908.1 | hisF | SAMN05443547_2284 | SAMN05443547_2511 | Phosphoserine phosphatase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.812 |
SHO73908.1 | hisG | SAMN05443547_2284 | SAMN05443547_2517 | Phosphoserine phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.404 |
SHO73908.1 | hisH | SAMN05443547_2284 | SAMN05443547_2513 | Phosphoserine phosphatase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.708 |
SHO73908.1 | hisI | SAMN05443547_2284 | SAMN05443547_2510 | Phosphoserine phosphatase. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.970 |
SHO73908.1 | trpF | SAMN05443547_2284 | SAMN05443547_2026 | Phosphoserine phosphatase. | Phosphoribosylanthranilate isomerase; Manually curated; Belongs to the TrpF family. | 0.930 |
hisA | SHO73908.1 | SAMN05443547_2512 | SAMN05443547_2284 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Phosphoserine phosphatase. | 0.715 |
hisA | hisB | SAMN05443547_2512 | SAMN05443547_2514 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.997 |
hisA | hisC | SAMN05443547_2512 | SAMN05443547_2515 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.982 |
hisA | hisD | SAMN05443547_2512 | SAMN05443547_2516 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
hisA | hisF | SAMN05443547_2512 | SAMN05443547_2511 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SAMN05443547_2512 | SAMN05443547_2517 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.992 |
hisA | hisH | SAMN05443547_2512 | SAMN05443547_2513 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SAMN05443547_2512 | SAMN05443547_2510 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |