Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
rseCPutative sigma-E factor regulatory protein. (142 aa)    
Predicted Functional Partners:
rseA
Putative sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cyto [...]
 
  
 0.850
lcfA
long-chain-fatty-acid--CoA ligase.
       0.755
rpoE
RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily.
  
  
 0.654
degS
Protease DegS precursor.
  
  
 0.625
htrA
Probable periplasmic serine protease do/hhoA-like precursor; Belongs to the peptidase S1C family.
  
  
 0.601
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
       0.564
dsbA
Thiol:disulfide interchange protein dsbA precursor.
  
  
 0.558
rnfG
Electron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
 
     0.522
APL_0584
Hypothetical protein; Belongs to the UPF0352 family.
  
     0.519
rnfC
Electron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
 
   
 0.451
Your Current Organism:
Actinobacillus pleuropneumoniae
NCBI taxonomy Id: 416269
Other names: A. pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae L20, Actinobacillus pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae serovar 5b strain L20
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