| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APL_0584 | rseA | APL_0584 | APL_0395 | Hypothetical protein; Belongs to the UPF0352 family. | Putative sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cyto [...] | 0.620 |
| APL_0584 | rseC | APL_0584 | APL_0396 | Hypothetical protein; Belongs to the UPF0352 family. | Putative sigma-E factor regulatory protein. | 0.519 |
| degS | rpoE | APL_0742 | APL_0394 | Protease DegS precursor. | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. | 0.669 |
| degS | rseA | APL_0742 | APL_0395 | Protease DegS precursor. | Putative sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cyto [...] | 0.941 |
| degS | rseC | APL_0742 | APL_0396 | Protease DegS precursor. | Putative sigma-E factor regulatory protein. | 0.625 |
| dsbA | rseC | APL_1868 | APL_0396 | Thiol:disulfide interchange protein dsbA precursor. | Putative sigma-E factor regulatory protein. | 0.558 |
| htrA | rseA | APL_1293 | APL_0395 | Probable periplasmic serine protease do/hhoA-like precursor; Belongs to the peptidase S1C family. | Putative sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cyto [...] | 0.863 |
| htrA | rseC | APL_1293 | APL_0396 | Probable periplasmic serine protease do/hhoA-like precursor; Belongs to the peptidase S1C family. | Putative sigma-E factor regulatory protein. | 0.601 |
| lcfA | rpoE | APL_0397 | APL_0394 | long-chain-fatty-acid--CoA ligase. | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. | 0.400 |
| lcfA | rseA | APL_0397 | APL_0395 | long-chain-fatty-acid--CoA ligase. | Putative sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cyto [...] | 0.422 |
| lcfA | rseC | APL_0397 | APL_0396 | long-chain-fatty-acid--CoA ligase. | Putative sigma-E factor regulatory protein. | 0.755 |
| lcfA | upp | APL_0397 | APL_0398 | long-chain-fatty-acid--CoA ligase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.580 |
| rnfC | rnfG | APL_0167 | APL_0170 | Electron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | Electron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. | 0.999 |
| rnfC | rseC | APL_0167 | APL_0396 | Electron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | Putative sigma-E factor regulatory protein. | 0.451 |
| rnfG | rnfC | APL_0170 | APL_0167 | Electron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. | Electron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | 0.999 |
| rnfG | rseC | APL_0170 | APL_0396 | Electron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. | Putative sigma-E factor regulatory protein. | 0.522 |
| rpoE | degS | APL_0394 | APL_0742 | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. | Protease DegS precursor. | 0.669 |
| rpoE | lcfA | APL_0394 | APL_0397 | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. | long-chain-fatty-acid--CoA ligase. | 0.400 |
| rpoE | rseA | APL_0394 | APL_0395 | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. | Putative sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cyto [...] | 0.994 |
| rpoE | rseC | APL_0394 | APL_0396 | RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily. | Putative sigma-E factor regulatory protein. | 0.654 |