Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
cpxRTranscriptional regulatory protein CpxR. (242 aa)    
Predicted Functional Partners:
APL_0627
Two-component sensor protein.
 
 0.989
APL_0935
Aerobic respiration control sensor protein.
 
 
 0.987
qseC
Sensor protein QseC.
 
 
 0.916
phoR
Phosphate regulon sensor protein PhoR.
 
 
 0.886
rpoD
RNA polymerase sigma factor 70; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.696
narP
Nitrate/nitrite response regulator protein.
  
 
 0.695
APL_0628
Hypothetical protein.
     
 0.624
cpxA
ATP-binding protein; Pubmed:9169799.
   
  
 0.620
rpoE
RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.616
pgaA
Biofilm PGA synthesis protein PgaA precursor.
      
 0.605
Your Current Organism:
Actinobacillus pleuropneumoniae
NCBI taxonomy Id: 416269
Other names: A. pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae L20, Actinobacillus pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae serovar 5b strain L20
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