| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cydC | metN | APL_0826 | APL_0912 | Transport ATP-binding protein CydC. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.767 |
| cysS | metI | APL_0913 | APL_0911 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | D-methionine transport system permease protein MetI. | 0.446 |
| cysS | metK | APL_0913 | APL_1080 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.447 |
| cysS | metN | APL_0913 | APL_0912 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.539 |
| cysS | plpA | APL_0913 | APL_0910 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Outer membrane lipoprotein 1 precursor; Belongs to the nlpA lipoprotein family. | 0.407 |
| metF | metI | APL_0854 | APL_0911 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | D-methionine transport system permease protein MetI. | 0.414 |
| metF | metJ | APL_0854 | APL_1917 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Transcriptional repressor protein MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.676 |
| metF | metK | APL_0854 | APL_1080 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.713 |
| metF | metN | APL_0854 | APL_0912 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.548 |
| metF | plpA | APL_0854 | APL_0910 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Outer membrane lipoprotein 1 precursor; Belongs to the nlpA lipoprotein family. | 0.400 |
| metF | plpB | APL_0854 | APL_0909 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Outer membrane lipoprotein 2 precursor; Belongs to the nlpA lipoprotein family. | 0.400 |
| metF | thrA | APL_0854 | APL_0250 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.853 |
| metI | cysS | APL_0911 | APL_0913 | D-methionine transport system permease protein MetI. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.446 |
| metI | metF | APL_0911 | APL_0854 | D-methionine transport system permease protein MetI. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.414 |
| metI | metN | APL_0911 | APL_0912 | D-methionine transport system permease protein MetI. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.999 |
| metI | plpA | APL_0911 | APL_0910 | D-methionine transport system permease protein MetI. | Outer membrane lipoprotein 1 precursor; Belongs to the nlpA lipoprotein family. | 0.999 |
| metI | plpB | APL_0911 | APL_0909 | D-methionine transport system permease protein MetI. | Outer membrane lipoprotein 2 precursor; Belongs to the nlpA lipoprotein family. | 0.998 |
| metJ | metF | APL_1917 | APL_0854 | Transcriptional repressor protein MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.676 |
| metJ | metK | APL_1917 | APL_1080 | Transcriptional repressor protein MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.437 |
| metJ | metN | APL_1917 | APL_0912 | Transcriptional repressor protein MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | D-methionine transport ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.414 |