Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
apxIIARTX-II toxin determinant A. (956 aa)    
Predicted Functional Partners:
apxID
RTX-I toxin secretion component.
 
  
 0.931
apxIIB
Leukotoxin translocation ATP-binding protein LktB (apxIIB).
 
  
 0.927
apxIB
Toxin RTX-I translocation ATP-binding protein; Pubmed:8181764.
 
  
 0.915
apxIC
RTX-I toxin-activating lysine-acyltransferase ApxIC; Pubmed:8359891.
 
   
 0.915
tbpA-2
Transferrin-binding protein 1 Tbp1.
  
 
   0.817
APL_0246
Truncated transferrin-binding protein 1 precursor.
  
 
   0.806
APL_1299
Predicted TonB dependent/Ligand-Gated channel.
  
 
   0.779
frpB
Iron-regulated outer membrane protein B.
  
 
 
 0.748
APL_1635
Putative adhesin processing HmwC-like protein; Inverting glycosyltransferase that catalyzes the transfer of one glucose moiety from UDP-glucose to an asparagine residue in peptides and proteins containing the NX(S/T) motif, resulting in their modification with a beta-linked 1,N-glucose. Likely acts as a key component of a general protein glycosylation system (Probable).
  
   
 0.694
APL_2002
Hypothetical protein.
  
     0.688
Your Current Organism:
Actinobacillus pleuropneumoniae
NCBI taxonomy Id: 416269
Other names: A. pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae L20, Actinobacillus pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae serovar 5b strain L20
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.