| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APL_0586 | APL_1607 | APL_0586 | APL_1607 | Putative RND efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Putative drug resistance protein. | 0.662 |
| APL_0586 | glnE | APL_0586 | APL_0969 | Putative RND efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.531 |
| APL_0586 | macA-2 | APL_0586 | APL_1814 | Putative RND efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Probable macrolide-specific efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.729 |
| APL_0586 | proP | APL_0586 | APL_0355 | Putative RND efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Bicyclomycin resistance-like protein. | 0.652 |
| APL_0935 | APL_1607 | APL_0935 | APL_1607 | Aerobic respiration control sensor protein. | Putative drug resistance protein. | 0.501 |
| APL_0935 | glnA | APL_0935 | APL_1941 | Aerobic respiration control sensor protein. | Glutamine synthetase. | 0.522 |
| APL_0935 | glnE | APL_0935 | APL_0969 | Aerobic respiration control sensor protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.550 |
| APL_0968 | APL_0970 | APL_0968 | APL_0970 | Hypothetical protein; Belongs to the UPF0231 family. | Hypothetical protein. | 0.403 |
| APL_0968 | glnE | APL_0968 | APL_0969 | Hypothetical protein; Belongs to the UPF0231 family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.532 |
| APL_0970 | APL_0968 | APL_0970 | APL_0968 | Hypothetical protein. | Hypothetical protein; Belongs to the UPF0231 family. | 0.403 |
| APL_0970 | glnE | APL_0970 | APL_0969 | Hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.653 |
| APL_1607 | APL_0586 | APL_1607 | APL_0586 | Putative drug resistance protein. | Putative RND efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.662 |
| APL_1607 | APL_0935 | APL_1607 | APL_0935 | Putative drug resistance protein. | Aerobic respiration control sensor protein. | 0.501 |
| APL_1607 | glnE | APL_1607 | APL_0969 | Putative drug resistance protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.613 |
| APL_1607 | macA-2 | APL_1607 | APL_1814 | Putative drug resistance protein. | Probable macrolide-specific efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.662 |
| APL_1607 | proP | APL_1607 | APL_0355 | Putative drug resistance protein. | Bicyclomycin resistance-like protein. | 0.722 |
| glnA | APL_0935 | APL_1941 | APL_0935 | Glutamine synthetase. | Aerobic respiration control sensor protein. | 0.522 |
| glnA | glnD | APL_1941 | APL_0598 | Glutamine synthetase. | Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.586 |
| glnA | glnE | APL_1941 | APL_0969 | Glutamine synthetase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.782 |
| glnD | glnA | APL_0598 | APL_1941 | Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Glutamine synthetase. | 0.586 |
