STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_0149KEGG: tma:TM1871 hypothetical protein. (90 aa)    
Predicted Functional Partners:
Tlet_0150
TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; KEGG: tma:TM1870 septum site-determining protein MinD.
  
 
 0.993
Tlet_0148
PFAM: protein of unknown function UPF0047; KEGG: tma:TM1872 hypothetical protein.
       0.790
Tlet_0812
Membrane protein-like protein; KEGG: mac:MA2663 hypothetical protein.
   
    0.672
Tlet_0122
TIGRFAM: signal peptidase I; PFAM: peptidase S24 S26A and S26B; KEGG: tma:TM1572 signal peptidase I; Belongs to the peptidase S26 family.
   
    0.659
Tlet_0660
PFAM: regulatory protein LacI; sigma-54 DNA-binding domain protein; Helix-turn-helix type 11 domain protein; KEGG: bld:BLi03678 RNA polymerase sigma factor; RBL03985.
   
    0.506
tuf
Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
    0.487
Tlet_0932
TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein; KEGG: tma:TM1734 phosphate transport system regulator PhoU, putative.
  
    0.465
Tlet_1698
Phosphate uptake regulator, PhoU; Plays a role in the regulation of phosphate uptake.
  
    0.438
Tlet_0170
TIGRFAM: ribonuclease, Rne/Rng family; KEGG: tma:TM1606 cytoplasmic axial filament protein, putative.
  
    0.418
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
    0.407
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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