STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_0489PFAM: restriction endonuclease; KEGG: tma:TM0932 hypothetical protein. (158 aa)    
Predicted Functional Partners:
Tlet_0490
Hypothetical protein.
       0.785
Tlet_0486
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
       0.762
Tlet_0487
KEGG: pgi:PG1071 hypothetical protein.
       0.762
Tlet_0488
TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; KEGG: ctc:CTC00890 L-lysine 2,3-aminomutase.
       0.762
Tlet_0485
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: tma:TM1638 ABC transporter, ATP-binding protein.
       0.695
Tlet_0491
TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator; KEGG: tma:TM1866 membrane bound protein LytR, putative.
       0.564
nfi
Deoxyribonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
       0.564
Tlet_0493
PFAM: iron-containing alcohol dehydrogenase; KEGG: tma:TM0920 alcohol dehydrogenase, iron-containing.
       0.546
Tlet_0494
KEGG: tma:TM1697 hypothetical protein.
       0.525
Tlet_0495
PFAM: aminotransferase class I and II; KEGG: tma:TM1698 aspartate aminotransferase.
       0.525
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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