STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_0517KEGG: tma:TM1704 hypothetical protein. (532 aa)    
Predicted Functional Partners:
lysS
TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: tma:TM1705 lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.839
Tlet_0523
Uncharacterised P-loop ATPase protein UPF0042; Displays ATPase and GTPase activities.
       0.813
Tlet_0526
KEGG: tma:TM1712 hypothetical protein.
       0.807
greA
Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
  
    0.806
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
     
 0.803
nrdR
ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
       0.799
whiA
Protein of unknown function DUF199; Involved in cell division and chromosome segregation.
       0.799
Tlet_0522
Protein of unknown function UPF0052 and CofD; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family.
       0.799
Tlet_0525
KEGG: tma:TM1711 hypothetical protein.
       0.773
Tlet_0527
TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase; KEGG: tte:TTE0844 histidine ammonia-lyase.
     
 0.597
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.