Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tlet_0620PFAM: type IV pilus assembly PilZ; KEGG: tma:TM0905 hypothetical protein. (234 aa)    
Predicted Functional Partners:
Tlet_0622
PFAM: GTP-binding signal recognition particle SRP54 G- domain; SMART: AAA ATPase; KEGG: tma:TM0907 flagellar biosynthesis protein FlhF.
 
  
 0.939
Tlet_0171
Flagellar hook-associated 2 domain protein; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
 
  
 0.935
Tlet_0617
TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma-70; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: tma:TM0902 RNA polymerase sigma-28 factor, putative.
  
  
 0.905
Tlet_0619
CheC, inhibitor of MCP methylation; PFAM: CheC domain protein; KEGG: tma:TM0904 chemotaxis protein CheC.
 
    0.886
Tlet_0630
PFAM: CheW domain protein; KEGG: tma:TM0701 purine-binding chemotaxis protein.
 
  
 0.880
Tlet_0631
CheA signal transduction histidine kinase; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; P2 response regulator binding domain protein; KEGG: tma:TM0702 chemotaxis sensor histidine kinase CheA.
  
  
 0.853
Tlet_0672
TIGRFAM: flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; KEGG: tma:TM0083 flagellar hook-associated protein 1.
 
  
 0.846
Tlet_1994
PFAM: flagellar protein FliS; KEGG: tma:TM1179 flagellar protein FliS.
  
  
 0.846
flhA
Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
  
  
 0.840
cheD
CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
  
    0.836
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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