STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (716 aa)    
Predicted Functional Partners:
Tlet_1992
PFAM: NUDIX hydrolase; KEGG: tma:TM1181 ADP-ribose pyrophosphatase.
   
 0.929
Tlet_0742
PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: tma:TM1595 hypothetical protein.
     
 0.815
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
    
 0.810
Tlet_0743
TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: tma:TM1594 conserved hypothetical protein, GGDEF domain.
       0.797
Tlet_0745
PFAM: alpha/beta hydrolase fold domain-containing protein; KEGG: pfu:PF0480 lysophospholipase.
       0.792
Tlet_1481
TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: tma:TM1741 putative tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
  
 
 0.759
Tlet_1714
PFAM: CBS domain containing protein; phosphoesterase RecJ domain protein; Polynucleotide adenylyltransferase region; phosphoesterase DHHA1; KEGG: tma:TM0715 tRNA nucleotidyltransferase (CCA-adding enzyme); Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
 
 0.708
Tlet_1651
PFAM: RNA binding S1 domain protein; KEGG: tma:TM1445 30S ribosomal protein S1.
  
 
 0.650
Tlet_1064
PFAM: ribosomal RNA adenine methylase transferase; KEGG: tma:TM1437 dimethyladenosine transferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
 
 
 0.648
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.608
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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